SAN FRANCISCO – A novel sirolimus-coated balloon (SCB) showed noninferior results to a clinically proven paclitaxel-coated balloon (PCB) in terms of late lumen loss (LLL) at 9 months post-implantation to treat coronary in-stent restenosis (ISR) from previously implanted drug-eluting stents (DES), according to a new randomized trial.