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VA Study Shows Need for Improvement in Distribution of Quadruple Therapy in Patients With HFrEF

Apr 01, 2026 by
Bailey G. Salimes, CRTonline.org

Not even one-quarter of veterans with heart failure with reduced ejection fraction (HFrEF) receive timely quadruple guideline-directed medical therapy (GDMT) after diagnosis of heart failure, a new study shows.

Women With Kidney Failure Have Lower Survival Rates vs Men After Multiarterial Grafting in CABG: Retrospective Study

Apr 01, 2026 by
Bailey G. Salimes, CRTonline.org

Men have a better chance of long-term survival compared with women after left internal mammary artery (LIMA) grafting plus multiarterial grafting (MAG) during coronary artery bypass grafting (CABG) in patients with kidney failure, a new study shows.

IVUS- and Angiography-Guided PCI Have Similar Outcomes in High-Risk, Complex PCI: IVUS-CHIP Study

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Routine intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) does not lower the risk of target vessel failure (TVF) compared with angiography-guided PCI, results from a randomized clinical trial show.

Chinese Study Indicates IVUS-Guided PCI Improves Outcomes in Complex Bifurcation Lesions Plus DK Crush Strategy

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Using intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for complex bifurcation lesions treated with the 2-stent DK crush technique improves some outcomes in patients at 1-year compared with angiography-guided PCI, results from the DKCRUSH VIII trial show.

OPTIMAL Trial Data Challenge Current Guidelines for LM Coronary Disease Treatment: IVUS vs Angiography

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Intravascular-ultrasound imaging (IVUS)-guided percutaneous coronary intervention (PCI) yields similar outcomes compared with angiography-guided PCI in patients with left main (LM) coronary artery disease (CAD), results from the OPTIMAL trial show.

Angiography With Sirolimus-Coated Balloon in SirPAD Study Improves Outcomes in Patients With PAD

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Data from the SirPAD trial show that angioplasty with sirolimus-coated balloons has better clinical outcomes compared with uncoated balloons in patients with infrainguinal artery disease receiving endovascular treatment.

Olezarsen, Standard Care Have Comparable Outcomes in Patients With Hypertriglyceridemia in ESSENCE-TIMI Trial

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Noncalcified coronary plaque volume is not impacted by significant triglyceride and remnant cholesterol lowering for 12 months with olezarsen therapy in addition to standard lipid lowering therapies, results from the ESSENCE-TIMI trial show.

Beta-Blocker Discontinuation Is Safe for Stable Heart Attack Patients: SMART-DECISION Trial

Mar 30, 2026 by
Bailey G. Salimes, CRTonline.org

Within 1-year after heart attack, outcomes are similar in patients who discontinue beta-blocker therapy versus patients who continue taking beta-blockers, demonstrating noninferiority in results from the SMART-DECISION trial.

T-TEER Reduces Deaths, HF Hospitalizations in Patients With Severe Tricuspid Regurgitation in TRI-FR Study

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Transcatheter tricuspid edge-to-edge repair (T-TEER) improves outcomes in patients with severe tricuspid regurgitation (TR), such as cutting heart failure (HF) hospitalizations in half and reducing death rates, according to results from the TRI-FR trial.

Protect the Head to Head Trial Embolic Protection Device is Safe, Efficient in Patients Undergoing TAVR

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Using the Emboliner system is safe and feasible in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), according to results from the Protect The Head to Head study.

PRO-TAVI Trial Suggests Deferred PCI Until is Safe in High-Risk Patients With CAD Undergoing TAVI

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Deferring percutaneous coronary intervention (PCI) in transcatheter aortic valve implantation (TAVI) significantly reduces bleeding in patients with coronary artery disease (CAD) and is noninferior to the standard of PCI before TAVI, data from the PRO-TAVI trial show.

Mitral Valve-in-Valve is Safe in Patients With Failed Mitral Bioprosthesis, Superior to Redo-Surgery: SURVIV Trial

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Mitral valve-in-valve (ViV) implantation is superior to redo-surgery in patients with failed mitral bioprosthesis, results from the SURVIV trial show.

Non-Wire FFR Strategy is Noninferior to Pressure-Wire FFR-Guided Revascularization in FAST III Trial

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Patients with coronary artery disease (CAD) who undergo vessel fractional flow reserve (vFFR)-guided revascularization have similar 1-year outcomes compared with patients who undergo pressure-wire FFR-guided revascularization, indicating the noninferiority of vFFR versus pressure-wire-guided FFR in the FAST III trial.

ORBITA-CTO Study Shows Symptom Improvement After PCI for Chronic Total Occlusion

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Data from the ORBITA-CTO trial demonstrate chronic total occlusion (CTO) percutaneous coronary intervention (PCI) improves symptoms and quality-of-life in patients with single-vessel CTO and chronic chest pain.

Novel FFRangio System is Noninferior to Standard Care in Coronary Physiology Assessment: ALL-RISE Trial

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

Physiological assessment derived from angiographic images (FFRangio system) in patients with at least one intermediate coronary stenosis, who were considered for percutaneous coronary intervention (PCI), is noninferior to a pressure-wire-based strategy at 1-year in the ALL-RISE trial.

CHIP-BCIS3 Trial Shows Microaxial Flow Pump Does Not Improve Outcomes in Patients With Severe LV Dysfunction

Mar 29, 2026 by
Bailey G. Salimes, CRTonline.org

At 12-months follow-up, patients with severely poor left ventricular (LV) function and coronary artery disease who are undergoing complex percutaneous coronary intervention (PCI) do not have better outcomes with elective LV unloading with a microaxial flow pump, results from the CHIP-BCIS3 trial show.

Cardiac Outcomes Improve With Intense LDL-C-Lowering for Atherosclerosis in South Korean Study

Mar 28, 2026 by
Bailey G. Salimes, CRTonline.org

Results from the Ez-PAVE trial show that intensive lowering of low-density lipoprotein cholesterol (LDL-C) levels further improves 3-year clinical outcomes compared with conventional LDL-C-lowering strategies in patients with atherosclerosis.

Evolocumab Preventative Against MACE in Patients With Diabetes and no Known Atherosclerosis: VESALIUS-CV Sub-Study

Mar 28, 2026 by
Bailey G. Salimes, CRTonline.org

The lipid-lowering therapy evolocumab reduces the risk of adverse cardiovascular events in high-risk patients who have diabetes but no known significant atherosclerosis, a secondary analysis of the VESALIUS-CV trial shows.

Patients With Heart Attacks Do Not Benefit From Delayed PCI, LV Support in STEMI-Door to Unload Trial

Mar 28, 2026 by
Bailey G. Salimes, CRTonline.org

Infarct size is not reduced, and there are more complications, in patients with anterior ST-segment myocardial infarction (STEMI) without shock if they receive a combination of a trans-valvular micro-axial flow pump (TV-mAFP) plus delayed percutaneous coronary intervention (PCI) versus PCI alone, results from the STEMI-Door to Unload trial show.

LAAC Comparable to Anticoagulants in Patients With AFib: CHAMPION-AF 3-Year Results

Mar 28, 2026 by
Bailey G. Salimes, CRTonline.org

Left atrial appendage closure (LAAC) is noninferior to blood thinner medications in patients with atrial fibrillation (AF) who qualify to receive anticoagulant therapy, results from the CHAMPION-AF trial show.

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