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Addressing Peridevice Leak in LAAO Requires ‘Holistic Approach’ to Prevention and Treatment, Review States

Mar 27, 2023 by
Nathan Gray, CRTonline.org

Despite recent advances and increasing adoption, certain issues with left atrial appendage occlusion (LAAO) remain, including the frequency of peridevice leak (PDL), which has been shown to confer a higher risk for subsequent ischemic events, warns a new review.

Hematopoietic Somatic Mosaicism Associated with Increased AF Risk

Mar 27, 2023 by
Nathan Gray, CRTonline.org

Assessment of patients for hematopoietic somatic mosaicism (HSM) genes may be useful in the personalized management of aortic valve replacement (AVR) patients, according to new research that identifies a high prevalence of HSM in surgical candidates.

Study Backs Novel Commissural Alignment Technique in TAVR Patients With ACURATE Neo2

Mar 27, 2023 by
Nathan Gray, CRTonline.org

New data from the first large consecutive evaluation of commissural alignment using a novel technique across all patients receiving an ACURATE Neo2 transcatheter aortic valve replacement (TAVR) device show that alignment was achieved in nearly all patients without safety concerns or impact to procedure duration.

AGT Levels Differ Between Sexes, Ethnic Groups, Study Concludes

Mar 27, 2023 by
Will Chu, CRTonline.org

Angiotensinogen (AGT) blood concentrations differ significantly between men and women and between racial/ethnic groups, says a new study that emphasizes the need for new therapies to better treat hypertension and heart failure.

Leaflet Morphology Not a Factor in Cardioband Success or Efficacy, Study Concludes

Mar 27, 2023 by
Will Chu, CRTonline.org

Leaflet morphology does not affect the efficacy and safety of transcatheter direct annuloplasty using Cardioband that reduces tricuspid regurgitation (TR) grade and heart failure symptoms, a new study finds.

Moderate Aortic Stenosis Linked to Higher Hospitalization, Death Rates in HFrEF Patients, Study Finds

Mar 27, 2023 by
Will Chu, CRTonline.org

In patients with heart failure with reduced ejection fraction (HFrEF), moderate aortic stenosis (AS) is linked to higher rates of heart failure (HF) hospitalization and mortality when compared to those without AS and even severe AS, new research concludes.

Balloon Pulmonary Angioplasty Has Grown Safer as Treatment for CTEPH – Systematic Review

Mar 22, 2023 by
Bailey Salimes, CRTonline.org

Balloon pulmonary angioplasty (BPA) has naturally become safer due to its increasing usage over the years, a new analysis shows.

Up-Titrating GDMT after M-TEER for Secondary MR in HFrEF Patients Associated with Better Outcomes – European Registry Analysis

Mar 22, 2023 by
Jason Wermers, CRTonline.org

Among patients with heart failure with reduced ejection fraction (HFrEF) undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) for treatment of secondary mitral regurgitation (SMR), increasing the dosage of guideline-directed medical therapy (GDMT) after M-TEER was associated with marked improvement in MR, survival and freedom from HF hospitalization (HFH), a new registry analysis shows.

Researchers Call for Comprehensive Psychosocial Care to Be Included in Severe PAD Management

Mar 20, 2023 by
Bailey Salimes, CRTonline.org

Mental health is a key, but often overlooked, aspect that should be included in treatment and follow-up of patients with severe peripheral artery disease (PAD), researchers urge in a newly published review article.

Culprit-Lesion-Only PCI Remains Preferred Strategy in Multivessel Disease with Cardiogenic Shock and Cardiac Arrest – CULPRIT-SHOCK Analysis

Mar 20, 2023 by
Jason Wermers, CRTonline.org

More than half of patients with infarct-related cardiogenic shock (CS) also experienced cardiac arrest (CA), which a new analysis of the CULPRIT-SHOCK randomized trial shows was an independent predictor of mortality at 1-year follow-up.

Timing of Valve Fracture Helps Determine Safety, Efficacy When Used in Conjunction with VIV TAVR – TVT Analysis

Mar 13, 2023 by
Ilan Merdler, CRTonline.org

Bioprosthetic valve fracture (BVF) as an adjunct to valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 and SAPIEN 3 Ultra valves is associated with a higher risk for in-hospital mortality and significant bleeding, with modest improvements in echocardiography-derived hemodynamic status, and the timing of BVF is a key factor in the procedure’s safety and efficacy, new study results show.

Third-Generation TEER System Provides Substantial MR Reduction at 1 Year: EXPAND Study

Mar 13, 2023 by
Sukhdeep Bhogal, CRTonline.org

The third-generation MitraClip NTR/XTR transcatheter edge-to-edge repair (TEER) system resulted in significant reduction in mitral regurgitation (MR) in contemporary real-world practice, compared to earlier randomized controlled trials, according to new registry results.

ViV on Degenerated Internally Stented Bioprosthetic Valves Is Safe, Retrospective Study Shows

Mar 13, 2023 by
Jason Wermers, CRTonline.org

Despite a higher risk of coronary obstruction with degenerated internally stented bioprosthetic valves, performing valve-in-valve (ViV) procedures in patients with these valves shows a similar rate of 3-year survival to ViV procedures in other degenerated bioprosthetic valves, a single-center retrospective study suggests.

Valve Underexpansion in ViV TAVR Produces Worse Hemodynamic Outcomes – Single-Center Study

Mar 13, 2023 by
Bailey Salimes, CRTonline.org

Valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) often produces results in underexpansion of the functional portion of transcatheter heart valve (THV) prostheses, particularly when these are deeply implanted, which leads to worse hemodynamics, a new study shows.

Intraprocedural Residual MR Predicts 1-Year Mortality after Mitral TEER – MITRA-PRO Registry

Mar 13, 2023 by
Pavan Reddy, CRTonline.org

Among all comers receiving mitral transcatheter edge-to-edge repair (TEER), intraprocedural residual mitral regurgitation (MR) with MitraScore ≥4 was associated with increased rate of mortality at 1 year, a multicenter registry study shows.

Abbott Executive Inspires Women in Heart Symposium Audience at CRT 2023

Mar 08, 2023 by
Jason Wermers, CRTonline.org

Julie Tyler, the president of Abbott’s vascular business, used the story of her daughter as a prime example of her charge to the audience during the keynote for the Women in Heart Symposium at CRT 2023 in Washington, D.C.: When you go about your work seeing patients, enrolling subjects in clinical trials, or compiling reports with statistics about those trials, remember that there are people behind those names and numbers.

LODESTAR Trial: ‘Treat-to-Target’ Statin Therapy Noninferior to High-Intensity Regimen in CAD Patients

Mar 06, 2023 by
Jason Wermers, CRTonline.org

A strategy of using moderate statin therapy and adjusting until a target low-density lipoprotein cholesterol (LDL-C) level of 50 to 70 mg/dL was achieved was noninferior to a high-intensity statin regimen at 3 years in patients with coronary artery disease (CAD), new randomized trial results show.

Inflammation a Stronger Predictor of CV Event Risk Than Cholesterol Levels, Trial Review Finds

Mar 06, 2023 by
Will Chu, CRTonline.org

Inflammation is a stronger predictor for risk of future cardiovascular events and death than cholesterol levels, according to a collaborative analysis of three randomized trials.

Oral PCSK9 Inhibitor MK-0616 Significantly Reduces LDL-C vs. Placebo at 8 Weeks: Randomized Trial

Mar 06, 2023 by
Jason Wermers, CRTonline.org

Using varying dosage levels, the oral PCSK9 inhibitor MK-0616 significantly and clinically reduced low-density lipoprotein cholesterol (LDL-C) in patients with hypercholesterolemia and a wide range of atherosclerotic cardiovascular disease (ASCVD) risk and background statin therapy compared to placebo after 8 weeks, new randomized trial results show.

Study: Troponin-I Levels Detected by Transdermal Wrist-Worn Device May Improve Diagnostics, Evaluation of AMI Patients

Mar 06, 2023 by
Bailey Salimes and Jason Wermers, CRTonline.org

Patients with acute myocardial infarction (AMI) may have improved early diagnosis and risk stratification when a wrist-worn transdermal infra-red spectrophotometric sensor (ISS) is used for bloodless estimation of elevated Troponin I (Trop-I) levels, a new study shows.

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