In patients with complex coronary artery disease (CAD) deemed ineligible for coronary artery bypass grafting (CABG), treatment with percutaneous coronary intervention (PCI) plus guideline-directed medical therapy (GDMT) was associated with short-term mortality that was similar to predicted mortality using surgical risk models, lower than the evaluating surgeon’s estimates of mortality risk with bypass surgery, yet substantially higher than predicted using PCI risk models, a new registry analysis shows.