A strategy of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR) demonstrated significantly lower event rates, including mortality, at 1 year, than a strategy of coronary artery bypass graft (CABG) and surgical aortic valve replacement (SAVR), in patients with concomitant complex coronary artery disease (CAD) and severe aortic stenosis (AS), new randomized trial results show.