Fractional flow reserve (FFR)–guided complete revascularization of non-culprit lesions did not lower the risk of death from any cause, myocardial infarction (MI), or unplanned revascularization than culprit-lesion-only percutaneous coronary intervention (PCI), among patients with ST-segment elevation myocardial infarction (STEMI) or very-high-risk non-STEMI (NSTEMI) and multivessel coronary artery disease, new trial results show.