The American College of Cardiology (ACC) Scientific Sessions 2021 will be held completely online, marking the second consecutive year that the meeting will be virtual. ACC was the first major cardiology conference to be held virtually after the COVID-19 pandemic brought a wave of lockdowns in the U.S. in March 2020 in an effort to slow the spread of the novel coronavirus. As planning began for ACC 2021, the organization announced that the meeting would be a hybrid, held partially in person in Atlanta and partially online, with all content accessible virtually. In its announcement this week, ACC 2021 Chair Pamela B. Morris, MD, and Vice Chair Douglas E. Drachman, MD, cited “the continued presence of COVID-19 and a sudden, sharp increase in ongoing travel restrictions imposed by health care institutions, academic medical centers and exhibitor companies” in making the decision to transition to a fully virtual meeting from May 15-17. “While we are saddened that we will need to wait another year before seeing everyone in person, plans for ACC.21 are continuing but as an all virtual experience!,” Morris and Drachman said in a widely distributed email announcing the decision. “Building on the success of last year’s meeting, ACC.21 will be a world-class program delivered through an innovative digital platform built for learning, collaboration, and networking. ACC.21 will also offer a robust virtual Expo with both exhibits and education from our signature Learning Destinations and, last but not least, more opportunities for you to engage and interact with your colleagues from around the world.” Every major cardiology meeting has been held virtually since the pandemic has taken hold globally. The last in-person meeting was Cardiovascular Research Technologies (CRT) 2020, held in February 2020 in National Harbor, Maryland. This year’s CRT also is being held virtually on Fridays and Saturdays through April 24 and has been renamed CRT 2021 Virtual.