When introduced in the clinical practice of interventional cardiology, bioresorbable vascular scaffolds (BVS) were initially indicated for only a limited number of indications: uncomplicated, so-called simple lesions with no calcifications and no tortuosity. After the first promising results with the first generation of BVS (the polymer-based Absorb), indications were extended to more complex lesions. Chronic total occlusions (CTO) and bifurcation lesions have known inferior results, directly during the procedure and in the long term, specifically in terms of restenosis. For these lesions, there is a need for another concept of stenting. Moreover, the characteristics of these BVS in CTO lesions should avoid full metal jackets and avoid lifelong side branch obstruction by overhanging struts in bifurcation lesions. Restoring normal vascular endothelial function seems, at least theoretically, to be a better solution for these kinds of difficult-to-treat lesions.