<h2 class="section-title u-h3 u-margin-l-top u-margin-xs-bottom">Abstract</h2> <div id="as0005"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0010">Background</h3> <p id="sp0060"><span>The association between post-operative <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/diastolic-blood-pressure" title="Learn more about diastolic blood pressure from ScienceDirect's AI-generated Topic Pages" class="topic-link">diastolic blood pressure</a> (DBP) and pulse pressure (PP) with outcomes following <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/percutaneous-aortic-valve-replacement" title="Learn more about transcatheter aortic valve replacement from ScienceDirect's AI-generated Topic Pages" class="topic-link">transcatheter aortic valve replacement</a> (TAVR) remains unclear. We sought to assess the prevalence, predictors, and impact of post-operative DBP and PP on presence of post-procedural </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-insufficiency" title="Learn more about aortic insufficiency from ScienceDirect's AI-generated Topic Pages" class="topic-link">aortic insufficiency</a> (AI) and mortality in adults undergoing TAVR.</p> </div> <div id="as0010"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0015">Methods</h3> <p id="sp0065">The study population included 194 patients who underwent TAVR from 2016 to 2017 at an academic tertiary medical center, of which 176 had invasive <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/arterial-pressure" title="Learn more about arterial pressures from ScienceDirect's AI-generated Topic Pages" class="topic-link">arterial pressures</a> available postoperatively. Low DBP and widened PP were defined as ≤40 mmHg and ≥80 mmHg respectively on invasive arterial line on post-operative day 1. Clinical outcomes of interest included post-procedural AI and 1-year all-cause mortality.</p> </div> <div id="as0015"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0020">Results</h3> <p id="sp0070">Post-operative low DBP and widened PP were noted in 32.4% and 58.5% of the study population. No significant association between post-operative AI and low DBP (p = 0.82) or widened PP (p = 0.32) was noted. There was a trend toward higher rates of mortality in patients with low DBP (19.3% vs 9.2%, p = 0.06) but no difference in mortality in patients with widened PP (10.7% vs 15.1%, p = 0.39) or those with ≥1+ post-procedural AI (16.7% vs 10.7%, p = 0.32). In multivariable analysis, low DBP was associated with a trend toward higher rates of 1-year mortality [odds ratio (OR) 2.43, 95% confidence interval (CI) 0.97–6.11, p = 0.06]. When excluding patients with a post-operative invasive <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/systolic-blood-pressure" title="Learn more about systolic blood pressure from ScienceDirect's AI-generated Topic Pages" class="topic-link">systolic blood pressure</a> < 80 mmHg, low DBP was associated with significantly higher risk-adjusted mortality at 1 year [OR 2.75, 95% CI (1.07–7.07), p = 0.04].</p> </div> <div id="as0020"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0025">Conclusions</h3> <p id="sp0075">In this contemporary study of adults undergoing TAVR, low DBP and widened PP were widely prevalent post TAVR. Low DBP was associated with a trend toward higher rates of 1-year mortality but not with post-procedural AI.</p> </div>