A curious, but important, collateral impact of the shelter-in-place requirements occurring during the COVID-19 pandemic has been the reduction in patients presenting with acute vascular events such as myocardial infarctions and cerebrovascular accidents. This has likely led to increased out-of-hospital mortality, but also likely late-term complications in survivors. One of these late-term post-myocardial infarction complications is the development of a post-infarct ventricular septal defect (VSD), and there have been whisperings that these have been seen more commonly during the pandemic. Therefore, it is timely to have an article re-assessing the management of patients with a post-infarct VSD, particularly with respect to the appropriate timing of closure.