1 Introduction Endovascular mechanical thrombectomy (MT) has become the mainstay therapy for acute stroke caused by large vessel occlusion. However, due to a lack of trainees and specialized centers, this therapeutical option is not available for a large part of the population. Therefore, interventional cardiologists joined interdisciplinary stroke teams to allow more widespread availability of MT, particularly in underserved areas. They have endovascular skills and are accustomed to handling acute and time-dependent percutaneous interventions. It remains unclear if the timing of the procedure (i.e., regular working hours [RH] vs. on-call [OC]) influences quality, time-effectiveness, and outcomes in this particular setting.