<h2 class="section-title u-h4 u-margin-l-top u-margin-xs-bottom">Abstract</h2> <div id="as0005"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0010">Background</h3> <p id="sp0095"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/patient" title="Learn more about Patients from ScienceDirect's AI-generated Topic Pages" class="topic-link">Patients</a><span> with <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-stenosis" title="Learn more about aortic stenosis from ScienceDirect's AI-generated Topic Pages" class="topic-link">aortic stenosis</a> (AS) usually have concomitant calcified <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/coronary-artery-disease" title="Learn more about coronary artery disease from ScienceDirect's AI-generated Topic Pages" class="topic-link">coronary artery disease</a> (CAD) requiring <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/atherectomy" title="Learn more about atherectomy from ScienceDirect's AI-generated Topic Pages" class="topic-link">atherectomy</a> to improve lesion compliance and odds of successful percutaneous coronary intervention (PCI). However, there is a paucity of data regarding PCI with or without atherectomy <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/inpatient" title="Learn more about in patients from ScienceDirect's AI-generated Topic Pages" class="topic-link">in patients</a> with AS.</span></p> </div> <div id="as0010"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0015">Methods</h3> <p id="sp0100">The National Inpatient Sample (NIS) database was queried from 2016 through 2019 using ICD-10 codes to identify individuals with AS who underwent PCI with or without atherectomy (Orbital Atherectomy [OA], Rotational or Laser Atherectomy [non-OA]). Temporal trends, safety, outcomes, costs, and correlates of major adverse cardiovascular events (MACE) were assessed using discharge weighted data.</p> </div> <div id="as0015"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0020">Results</h3> <p id="sp0105">Hospitalizations of 45,420 AS patients undergoing PCI with or without atherectomy were identified and of those, 88.6 %, 2.3 %, and 9.1 % were treated with PCI-only, OA, or non-OA, respectively. There was an increase in PCIs (8855 to 10,885), atherectomy [OA (165 to 300) and non-OA (795 to 1255)], and<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/intravascular-ultrasound" title="Learn more about intravascular ultrasound from ScienceDirect's AI-generated Topic Pages" class="topic-link">intravascular ultrasound</a><span> </span>(IVUS) use (625 to 1000). The median cost of admission was higher in the atherectomy cohorts ($34,340.77 in OA, $32,306.2 in non-OA) as compared to the PCI-only cohort ($23,683.98). Patients tend to have decreased odds of MACE with IVUS guided atherectomy and PCI.</p> </div> <div id="as0020"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0025">Conclusions</h3> <p id="sp0110">This large database revealed a significant increase in PCI with or without atherectomy in AS patients from 2016 to 2019. Considering the complex<span> </span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/comorbidity" title="Learn more about comorbidities from ScienceDirect's AI-generated Topic Pages" class="topic-link">comorbidities</a><span> </span>of AS patients, the overall complication rates were well distributed among the different cohorts, suggesting that IVUS guided PCI with or without atherectomy in patients with AS is feasible and safe.</p> </div>