The France PCI Registry provides important insight into the contemporary prevalence, management, and impact of in-stent restenosis in a national, real-world, all-comer registry. Duband et al., report in this issue of Cardiovascular Revascularization Medicine , how more than 7 % of percutaneous coronary interventions (PCI) from the France PCI Registry were for in-stent restenosis, with the most common treatment type being with an additional drug-eluting stent (DES) . PCI outcomes for in-stent restenosis were associated with significantly greater target lesion failure compared with de novo PCI. These findings confirm what has been previously reported in the literature .