Peripheral arterial disease (PAD) is a chronic condition characterized by widespread atherosclerotic changes of arterial beds, most commonly of the lower extremities. An often-undiagnosed disease, the end-stage sequala of PAD includes disabling claudication that reduces patient mobility; lower-extremity ulcerations that serve as a nidus for infection and subsequent sepsis; and in its advanced form, critical limb ischemia (CLI) that might require limb amputation if untreated. Indeed, PAD is a critical co-morbid condition that needs to be identified and treated early in a multidisciplinary team in order to prevent the aforementioned late-stage complications from occurring. For this reason, a number of risk factors have been identified that increase a patient's risk for developing PAD such as family history, heart disease, or neurovascular disease . Furthermore, diabetes mellitus (DM) is a well-established risk factor that not only can lead to the development of PAD, but has been shown to result in a worsened disease state with increased incidence of all-cause mortality, increased risk of macrovascular and microvascular events, increased incidence of limb amputations and finally worse quality of life . Therefore, understanding the pathophysiology as well as treatment course in patients with PAD and DM is of critical importance to improving patient outcomes.