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  • Response to “Postoperative Myocardial Injury and Outcomes in Liver and Kidney Transplant Patients”

    We read with great interest the article by Yang et al. entitled “Postoperative Myocardial Injury and Outcomes in Liver and Kidney Transplant Patients”. Authors reported that myocardial injury after non-cardiac surgery (MINS) was predictive of major adverse cardiac events (MACE)  . However, we are surprised by their results as they differ from ours. We conducted a similar retrospective study at Grenoble University Hospital, and included 115 patients who underwent liver transplantation (LT). We aimed to determine the occurrence of MACE within the first 30 days following LT between patients with and without MINS, as defined in the fourth universal definition of myocardial infarction  . Patients undergoing dual liver-kidney transplantation and emergency transplantation were excluded. Seventy-nine patients (68 %) developed MINS. In our study, MINS was not associated with increased MACE at 30 days (HR = 1.03; 95 % CI [0.30–4.02]; p value = 0.965) and at 1 year (HR = 0.90; 95 % CI [0.08–19.9]; p value = 0.94), as shown in Fig. 1 . None of the MACE were lethal in our study. The main causes of death at 30 days were hemorrhage and multiple organ failure, while the main causes of death at one year were sepsis and multiple organ failure. Similar results were found in a recent prospective study in which MINS did not appear to be predictive of MACE within 7 days of LT in patients  . Several points should be discussed to explain our discrepancies. First, our study included exclusively liver transplant recipients. Although they have cardiovascular risk factors in common, liver and kidney transplant patients have a different cardiovascular risk profile. Related in particular to the initial disease, hemodynamic changes secondary to cirrhosis, and surgical risk, which is much greater in liver transplantation (hemorrhage, iterative clamping, reperfusion syndrome, duration of the surgery)  . As a result, we believe that these two populations should be studied separately. Second, we have included thromboembolic events and arrhythmias in the definition of MACE, as described in the literature  .

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