The current American Heart Association/American College of Cardiology/Heart Rhythm Society guidelines for the management of atrial fibrillation (AF) give a class IIb recommendation to percutaneous left atrial appendage occlusion (LAAO) in patients with AF at increased risk of stroke who have contraindications to long-term anticoagulation . After increasing adoption among patients with high bleeding risk, it is currently being investigated how LAAO compares to oral anticoagulation for primary and secondary stroke prevention among all comers with AF regardless of their risk for bleeding . Increasing rates of LAAO device deployment bring forth an important question, ‘are the available devices comparable in outcomes?’ Thus far comparative studies show conflicting results . Recent meta-analyses attempting to answer this question have included patients receiving older generation Amplatzer Cardiac Plug, thus limiting present-day applicability . The aim of this study is to provide a comprehensive and updated quantitative assessment of evidence about the safety and efficacy of Watchman device compared to Amulet.