Acute myocardial infarction (AMI)-related mortality in the United States has decreased significantly in the past 2 decades, with a report suggesting age-adjusted mortality rates (AAMR) of type 1 or 2 AMI decreasing from 134.7 in 1999 to 48.5 in 2019 per 100,000 population-year [ ]. This has been attributed to improved preventive and management strategies. Numerous studies have reported an increased risk of AMI in patients admitted with acute infection [ ]. The incidence of type 1 AMI among patients admitted with pneumococcal pneumonia was reported to be 7–8 %; however, this could be an underestimation considering the attribution of elevated troponin to troponin leak, secondary to demand-supply mismatch [ ], or an overestimation because of the above mentioned reason. Sepsis defined as an acute infection and ≥2 SOFA criteria represents an infection of higher acuity. Among patients with sepsis and documented AMI, there are limited data on the trend of mortality over the past 2 decades, and whether parallel changes in mortality trends were achieved in comparison with the overall AMI mortality.