The ascending aorta is a complex structure. The proximal aorta is composed of the ventricular outlet to the sinotubular junction and is referred to as the aortic root. From the sinotubular junction, the ascending aorta gives rise to the aortic arch, and the great vessels. The ascending aorta, collectively, is a complex mechanical unit, with dynamic forces being exerted on it with each cardiac cycle. Furthermore, the elastic fiber composition of the aorta necessitates tight regulation in order to withstand aortic forces. There are a number of mutations associated with ascending aortic pathology [ ].