1 Introduction An aneurysm of the sinus of Valsalva (SoV) is a rare acquired or congenital cardiac malformation that results from incomplete fusion of aortic media and the aortic valve annulus. ( 1 ) It predominantly affects the right and the non-coronary sinuses and has an estimated prevalence of 0.09 %. There is also ethnic variation in prevalence between Western and Asian populations. ( 2 , 3 ) When intact, aneurysm of SoV is usually asymptomatic. However, it can have deleterious hemodynamic consequences leading to acute heart failure, cardiac tamponade, acute coronary syndrome, or sudden death in case of rupture ( 4 ). Ruptured SoV (RSOV) aneurysms have been traditionally managed via urgent surgical repairs. However, there are many case reports and case series of successful percutaneous closure. More recently, case reports of transcatheter aortic valve replacement (TAVR) complicated by RSOV have been reported and percutaneous closure of these defects has also been documented. Here we present a review of the available case studies evaluating the percutaneous closure of RSOV aneurysms. We also examine the available evidence of percutaneous closure of RSOV after TAVR.