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  • Major coronary evaginations following implantation of bioresorbable vascular scaffolds – Clinical and OCT characteristics


    • Coronary evaginations after implantation of bioresorbable scaffolds are associated with progressive lumen enlargement.
    • Areas with evaginations are associated with higher rates of strut fracture and malapposed struts.
    • The area of scaffolds affected by evaginations increases over time.



    Coronary evaginations can occur after implantation of bioresorbable vascular scaffolds (BRS) and may be associated with scaffold thrombosis. Aim of this study was to clarify the clinical manifestation, extent and time course of coronary arteryremodeling in vessel segments that develop angiographically detectable evaginations following BRS implantation through optical coherence tomography (OCT) analysis.


    In 8 patients, 10 BRS (Absorb, Abbott Vascular, Santa Clara, CA, USA) which displayed coronary evaginations in clinically driven late invasive coronary angiograms were identified and findings were compared to 10 BRS in 8 patients without coronary evaginations. Vessel and device geometry was analyzed in serial OCT cross-sections at a spacing of 200 μm. Measured BRS dimensions were normalized to the reference vessel size at implantation.


    In OCT, major evaginations on average affected 24 ± 19% of the scaffold length. Scaffolds with major evaginations had a significantly larger lumen area than scaffolds without evaginations (mean normalized lumen area 1.19 ± 0.58 vs. 0.77 ± 0.38; p < 0.001), and also displayed a significantly larger scaffold area (mean normalized scaffold area: 1.36 ± 0.6 vs. 1.13 ± 0.43; p < 0.001), and scaffold diameter (mean normalized scaffold diameter: 1.17 ± 0.33 vs.1.04 ± 0.19; p < 0.001). Lumen area (r = 0.47; p < 0.001), scaffold area (r = 0.52; p < 0.001), and scaffold diameter (r = 0.74; p < 0.001) in the evagination group were positively correlated to the time since scaffold implantation.


    Coronary evaginations following BRS implantation are associated with an increased scaffold area, indicating that the scaffold follows the outward remodeling of the artery. The process affects the entire scaffold length and seems to be continuously progressing following implantation.

    Author bio

    Cardiovascular Revascularization Medicine, 2019-06-01, Volume 20, Issue 6, Pages 485-491, Copyright © 2018 Elsevier Inc.



    Read the full article on Science Direct: Major coronary evaginations following implantation of bioresorbable vascular scaffolds – Clinical and OCT characteristics

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