ADVISE |
2011 |
157 |
Multicenter, nonrandomized, observational, prospective |
Patients with coronary stenosis |
Valvular diseases, previous CABG c , contraindication to adenosine, increased troponin, and overweight |
0.8 |
0.83 |
VERIFY |
2013 |
206 |
Multicenter, nonrandomized, observational, prospective |
Patients with coronary stenosis required functional intracoronary assessment |
Prior CABG, extremely tortuous, calcified lesions, coronary artery occlusion, acute MI d within 5 days |
0.8 |
0.83 |
Park et al. |
2013 |
238 |
Multicenter, nonrandomized, observational, prospective |
Patients with coronary stenosis required functional intracoronary assessment |
In-stent restenosis, acute ST-segment elevation myocardial infarction, chronic total occlusion lesions, vessels with collateral feeders, regional wall motion abnormalities of a target vessel segment, left ventricular ejection fraction < 40%, primary myocardial or valvular disease, contraindication to adenosine, or angiographically visible thrombus of a target lesion |
0.8 |
0.9 |
ADVISE In PRACTICE |
2014 |
392 |
Multicenter, nonrandomized, observational, prospective |
Patients with coronary stenosis required functional intracoronary assessment |
Previous CABG, contraindication to adenosine administration |
0.8 |
0.9 |
Indolfi et al. |
2014 |
123 |
Single center, nonrandomized, observational, prospective |
Patients referred for coronary angiography who had multivessel disease with at least one intermediate stenosis in setting of ACS e |
Noncardiac life-threatening disease, requiring valvular surgery, cardiologist decided not to perform FFR to guide the treatment, hemodynamic instability, ongoing arrhythmias, valve disease, contraindication to adenosine administration |
0.8 |
0.92 |
ADVISE 2 2015 |
2015 |
690 |
Multicenter, nonrandomized, observational, prospective, double blind |
Patients with coronary stenosis required functional intracoronary assessment |
Previous CABG, contraindication to adenosine administration, increased troponin, and overweight |
0.8 |
0.89 |
Harle et al. |
2015 |
151 |
Single center, nonrandomized, observational, prospective |
Patients with coronary stenosis required functional intracoronary assessment |
Contraindications to adenosine administration |
0.8 |
0.896 |
Shiode et al. |
2016 |
123 |
Single center, nonrandomized, observational, prospective |
Mild or moderate stenosis who were undergoing coronary angiography |
– |
0.8 |
0.89 |
Kobayashi et al. (LM f/pLAD g ) |
2016 |
201 |
Multicenter, nonrandomized, observational, prospective |
18 years or older who underwent invasive physiological assessment of coronary artery lesions for standard clinical indications |
Previous CABG, an extremely tortuous or calcified coronary artery, known severe LVH h , left ventricular ejection fraction < 30%, inability to receive adenosine, renal insufficiency such that additional contrast would pose unwarranted risk, or recent (within 3 weeks before cardiac catheterization) ST-segment elevation myocardial infarction |
0.8 |
0.9 |
Kobayashi et al. (other lesions) |
2016 |
559 |
Multicenter, nonrandomized, observational, prospective |
18 years or older who underwent invasive physiological assessment of coronary artery lesions for standard clinical indications |
Previous CABG, an extremely tortuous or calcified coronary artery, known severe LVH, left ventricular ejection fraction < 30%, inability to receive adenosine, renal insufficiency such that additional contrast would pose unwarranted risk, or recent (within 3 weeks before cardiac catheterization) ST-segment elevation myocardial infarction |
0.8 |
0.9 |
VERIFY 2 |
2016 |
257 |
Single center, nonrandomized, observational, prospective |
18–90 years old with angiographically intermediate coronary stenoses in which FFR measurement was clinically indicated |
Severe calcific coronary disease, severe tortuosity rendering pressure wire studies difficult or impossible, recent myocardial infarction within 72 h, ongoing unstable chest pain, known intolerance of adenosine, or severe asthma |
0.8 |
0.9 |
Meimoun et al. |
2016 |
94 |
Single center, nonrandomized, observational, prospective |
Stable CAD i with 50–70% intermediate LAD jstenosis |
Hemodynamic instability, acute coronary syndrome involving the LAD as a culprit vessel, contra indication to adenosine, a stenosis in the distal part of the LAD, and two or more stenoses in the LAD |
0.8 |
0.88 |
Johnson et al. |
2016 |
763 |
Multicenter, nonrandomized, observational, prospective |
Undergoing routine FFR assessment for standard indications |
Previous coronary bypass surgery, known severe cardiomyopathy (left ventricular ejection fraction < 30%) or left ventricular hypertrophy (septal wall thickness > 13 mm), contraindication to adenosine, or renal insufficiency such that an additional 12 to 20 mL of contrast would pose an unwarranted risk |
0.8 |
0.9 |
Kanaji et al. |
2016 |
120 |
Single center, nonrandomized, observational, prospective |
Undergoing coronary angiography for suspected coronary artery disease with lesions in at least one epicardial proximal coronary artery that were angiographically intermediate (30–80% by visual estimation) |
History of CABG, tortuous coronary arteries, severely calcified arteries, acute coronary syndrome, history of myocardial infarction, occluded coronary arteries, left main disease, coronary ostial stenosis, congestive heart failure, significant arrhythmias, renal insufficiency (creatinine 1.5 mg/dL), or absolute contraindication to adenosine |
0.8 |
0.89 |
Fede et al. |
2015 |
89 |
Single center, nonrandomized, observational, prospective |
Undergoing coronary angiography for stable or unstable angina, or for non ST elevation myocardial infarction found to have intermediate stenosis of 50–70% by visual estimation |
ST-segment elevation myocardial infarction or hemodynamic unstable conditions |
0.8 |
0.89 |
RESOLVE |
2014 |
1593 |
Multicenter, nonrandomized, observational, retrospective |
Patients with stable angina, unstable angina, or non ST-segment myocardial infarction undergoing coronary angiography with or without percutaneous coronary intervention in whom FFR of a single stenosis in a major epicardial coronary artery was performed during the procedure |
Left main disease, heart failure as defined by New York Heart Association class III or IV, respiratory failure requiring intubation or supplementary oxygen, cardiogenic shock, significant arrhythmia precluding waveform analysis (examples include premature ventricular contractions or atrial fibrillation), and tachycardia with heart rate > 120 beats/min |
0.8 |
0.9 |