<h2 class="section-title u-h3 u-margin-l-top u-margin-xs-bottom">Abstract</h2> <div id="as0005"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0010">Background/purpose</h3> <p id="sp0040"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/intravascular-ultrasound" title="Learn more about Intravascular ultrasound from ScienceDirect's AI-generated Topic Pages" class="topic-link">Intravascular ultrasound</a><span> (IVUS) and near-infrared spectroscopy (NIRS) can identify vulnerable coronary <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/atherosclerotic-plaque" title="Learn more about atherosclerotic plaques from ScienceDirect's AI-generated Topic Pages" class="topic-link">atherosclerotic plaques</a>. We aimed to compare the presence or absence of baseline <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/intravascular-imaging" title="Learn more about intravascular imaging from ScienceDirect's AI-generated Topic Pages" class="topic-link">intravascular imaging</a> of non-culprit lesions and their subsequent adverse events.</span></p> </div> <div id="as0010"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0015">Methods/materials</h3> <p id="sp0045">We identified patients from the Lipid Rich Plaque (LRP) study who had a non-culprit-lesion adverse event and divided them into 2 cohorts: those with lesions detected with NIRS-IVUS imaging at baseline and those with lesions not imaged at baseline.</p> </div> <div id="as0015"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0020">Results</h3> <p id="sp0050">Overall, 73 patients had an adverse event (99 coronary segments) during the 24-month follow-up period. Among them, 41 patients (56.2%) had a non-culprit-lesion adverse event related to a coronary segment imaged at baseline, and 32 patients (43.8%) had a non-culprit-lesion adverse event adjudicated to a segment that was not scanned at baseline. Angiographic core laboratory analysis suggested that unscanned lesions were more often in the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/right-coronary-artery" title="Learn more about right coronary artery from ScienceDirect's AI-generated Topic Pages" class="topic-link">right coronary artery</a><span> (~50%); branches of the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/left-coronary-artery" title="Learn more about left coronary artery from ScienceDirect's AI-generated Topic Pages" class="topic-link">left coronary artery</a>, i.e., diagonal or left obtuse marginal arteries (~20%); smaller vessels; or more tortuous vessels; and less often in the left anterior descending or distal locations. There was a weak trend for acute severe events (adjudicated myocardial infarction and acute coronary syndrome) in patients with lesions not scanned at baseline (50.0% versus 36.6%, p = 0.250).</span></p> </div> <div id="as0020"> <h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0025">Conclusions</h3> <p id="sp0055">In patients with follow-up non-culprit-lesion adverse events, nearly half were not imaged with NIRS-IVUS at baseline. Because events related to non-imaged lesions were at least as severe as events related to imaged lesions, future clinical trials and clinical protocols should be designed to minimize this issue.</p> </div>