<h2 id="hl0000221">Abstract</h2> <h2 id="hl0000223">Background</h2> <p id="hl0000224">Gout is a common chronic inflammatory disease with increasing prevalence over the last decades. However, there is limited evidence on outcomes of PCI in patients with gout.</p> <h2 id="hl0000226">Methods</h2> <p id="hl0000227">A Retrospective cohort study of all adult patients who underwent PCI in a large [1000 bed] tertiary care center from January 2002 to August 2020. Patients were stratified according to a diagnosis of gout. The primary outcome was defined as the first event of all-cause mortality or major CV event that included acute coronary syndrome -(ACS) or congestive heart failure -(CHF) related admission. To examine the association between gout and outcome, a multi-variable cox proportional hazard model was used.</p> <h2 id="hl0000229">Results</h2> <p id="hl0000230">Out of 12,951 who patients underwent PCI during the study period, 344 (2.7%) had a diagnosis of gout. The study median follow-up time was 105 months. Patients with gout had significantly higher crude rates of clinical events (73.8% vs. 59.5%,<span> </span><i>p</i><span> </span>< 0.001). Gout was associated with increased risk for ACS and HF-admissions [HR 1.24 95%CI (1.07–1.43),<span> </span><i>p</i><span> </span>= 0.04; HR 1.99, 95%CI (1.57–2.54)<span> </span><i>p</i><span> </span>< 0.001, respectively], as well as for any clinical event (HR 1.2 95%CI (1.04–1.38),<span> </span><i>P</i><span> </span>= 0.01).</p> <h2 id="hl0000236">Conclusion</h2> <p id="hl0000237">Gout is associated with increased post-PCI cardiovascular risk. Therefore, patients with gout should be considered as a higher risk cohort.</p>