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  • Editorial: Search for Holy Grail of Stent Coating Will Go On

    Since the bare metal stent era, there has been a search for the optimal stent coating. This process was intensified with the rise of the concept of stents that carried antiproliferative drugs in polymer-based coatings and locally eluted them at the treatment site to prevent lesion recurrence  . The investigation of various more or less successful coating materials ultimately resulted in the relatively biocompatible durable or biodegradable polymer-based coatings that can be found on contemporary drug-eluting stents (DES)  . Still, novel DES with alternative coating technologies have been developed that primarily aim at early endothelial stent coverage. One of these concepts is to make use of endothelial progenitor cells (EPCs)  . The idea is that the local presence of EPCs may promote early endothelialization of implanted stents in order to reduce the risk of stent thrombosis, excessive neointimal proliferation and, ultimately, in-stent restenosis.

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