Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is a common but potentially serious complication leading to in-hospital mortality. The presentation can be acute or acute on chronic, if the patient has pre-existing chronic kidney disease (CKD). It occurs after administration of intravenous radiocontrast agents for computed tomography (CT) scans or intra-arterial for coronary angiography with or without percutaneous coronary intervention (PCI). The data regarding the use of nicorandil for reduction of CI-AKI are variable and inconclusive.