Bedogni et al. presented the results of the GIse registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO), confirming that in a real-world setting, functional mitral regurgitation (FMR) was the principal indication to MitraClip (MC) implantation in Italy over degenerative mitral regurgitation (DMR). This is a large registry of about 1200 patients, which included patients [1] in 22 Italian centers between February 2016 and December 2018. Of these, 64.9% were FMR patients, 24.8% were patients with DMR and 10.3% of patients had mixed etiology. The high rate (96.6%) of technical success in GIOTTO was consistent with international registries, such as ACCESS-EU. Many (>50%) patients required at least two clips to reach 87% procedural success, as measured at one month. The authors confirmed that the MC procedure was safe and effective, which is a consistent statement with all previous reports on MC.