The prevention of acute coronary syndromes (ACS) remains a core endeavor in the field of cardiology. Despite advances in preventative medicine and interventional procedures, the prevalence and impact of ACS on patients, and the healthcare system as a whole, remains tremendous. This is why, after decades of research, physicians continue to explore novel approaches to predict and prevent ACS. Part of that exploration depends on a deeper understanding of coronary plaques and the features that lead to ACS events.