Over the past few years, the incidence of complication rates, including bleeding complications, after percutaneous coronary intervention (PCI) has been decreasing. This is likely due to the use of new effective drugs and refinements in procedural techniques. However, the incidence of bleeding complications is still high in a certain subset of patients [ ]. Bleeding events post-PCI have been associated with significantly higher in-hospital and 30-day mortality, longer hospital stay and higher rates of readmission [ ]. A study in this issue of the journal by Bimal et al. showed that major bleeding complications are more common in women and in patients with chronic kidney disease (CKD). Interestingly, the authors found that obese women with CKD had a lower incidence of bleeding complications compared with overweight and normal-weight women undergoing PCI. The authors also noted that age, cardiogenic shock, ST segment elevation myocardial infarction, and use of mechanical circulatory support devices were associated with a higher bleeding event rate [ ].