Spontaneous coronary artery dissection (SCAD) is an uncommon and important cause of myocardial infarction (MI), particularly in young- to middle-aged women, resulting from the non-traumatic separation of the coronary arterial wall with the development of a false lumen. Takotsubo syndrome (TS) (also known as apical ballooning syndrome) is characterized by acute reversible left ventricular (LV) dysfunction with distinct wall motion abnormalities which typically occurs in postmenopausal women after a stressful event. SCAD and TS share many clinical similarities, including the predilection for women, ischemic electrocardiographic abnormalities, elevated cardiac biomarkers, and wall motion abnormalities that subsequently normalize.