• Association of high level of hs-CRP with in-stent restenosis: A case-control study


    • Presence of diabetes mellitus, previous implanted stent type and hs-CRP were the most important factors associated to occurrence of ISR.
    • Cut-off value of hs-CRP associated to ISR occurrence was lower than cut-off value defined before as a predicting factor for CHD.
    • In individuals hs-CRP > 2.64 mg/dL addition to presence of DM, bare stent and higher TG was associated with ISR.
    • In individuals with hs-CRP < 2.64 mg/dL, ISR was only associated with DM presence.
    • There was no association found between statin and ARBs and ISR occurrence.



    In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR.


    This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value ≤ 0.05 was considered significant.


    Diabetes mellitus (p < 0.001), stent type (p = 0.005), serum hs-CRP (p = 0.006), FBG (p = 0.038) and serum TG (p = 0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64 mg/dL, ISR was only associated with diabetes mellitus (p = 0.016); while for individuals with a serum hs-CRP ≥2.64 mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type.


    Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR.

    Author bio

    Cardiovascular Revascularization Medicine, 2019-07-01, Volume 20, Issue 7, Pages 583-587, Copyright © 2018 Elsevier Inc.



    Read the full article on Science Direct: Association of high level of hs-CRP with in-stent restenosis: A case-control study

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