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Hydroxychloroquine/Azithromycin Shows Prolonged QT Intervals, No Effect on Mortality in COVID-19

Aug 05, 2020 by
Brian C. Case, CRTonline.org

An increase in corrected QT (QTc) intervals was seen in hospitalized COVID-19 patients treated with hydroxychloroquine/azithromycin (HCQ/AZM), but these changes were not associated with an increased risk of death, according to a study released Wednesday.

TAVR Shows Higher Risk of Annular Rupture with Significant LVOT Calcium

Aug 03, 2020 by
Giorgio A. Medranda, CRTonline.org

The presence of left ventricular outflow tract (LVOT) calcium was associated with residual aortic regurgitation (AR), annular rupture, and the need for a second valve in transcatheter aortic valve replacement (TAVR), according to a single-center registry analysis.

Preclinical Study: LV Unloading Before Reperfusion Limits Myocardial Infarction Size

Aug 03, 2020 by
Charan Yerasi, CRTonline.org

Transvalvular ventricular unloading before reperfusion pump limits ischemic injury improves myocardial energy substrate use and preserves mitochondrial function after reperfusion, according to a new preclinical study.

Repositioning Evolut Valves During TAVR Appears Safe at 1 Year

Aug 03, 2020 by
Giorgio A. Medranda, CRTonline.org

Repositioning CoreValves during in transcatheter aortic valve replacement (TAVR) appears to be safe, with similar outcomes at 1 year to TAVR with non-repositionable valves, an analysis of two studies reports.

Transseptal Mitral ViV with SAPIEN 3 Valve Shows Good Results at 1 Year

Jul 30, 2020 by
Brian C. Case, CRTonline.org

A recent analysis of the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy (STS/ACC TVT) Registry shows that transcatheter mitral valve-in-valve (MViV) with the transseptal SAPIEN 3 valve (Edwards Lifesciences) was associated with rare procedural complications and low mortality.

High Myocardial Viral Load Detected in COVID-19 Patients, But Not Associated with Overt Myocarditis, Autopsy Study Shows

Jul 27, 2020 by
Giorgio A. Medranda, CRTonline.org

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was present in the myocardia of patients who died of COVID-19, but this was not associated with an increased inflammatory response, according to the results of a autopsy study.

ViV-TAVR Yields Improved Survival vs. Redo SAVR in Short Term, but Redo SAVR Gains Ground Over Time

Jul 27, 2020 by
Giorgio A. Medranda

In the largest propensity-score-matched comparison to date of patients who underwent valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) and those who underwent redo surgical aortic valve replacement (SAVR) for degenerated bioprostheses, ViV-TAVR was associated with a lower rate of all-cause mortality at 30 days but similar long-term mortality.

Post-MI NSAIDs Associated With Increased Risk of Cardiovascular, Bleeding Events

Jul 27, 2020 by
Charan Yerasi, CRTonline.org

The use of non-steroidal anti-inflammatory drugs (NSAIDs) after myocardial infarction (MI) is associated with an increased risk of cardiovascular and bleeding events, a new study from a large Korean national database shows.

CMR Shows High Cardiac Involvement in COVID-19 patients

Jul 27, 2020 by
Chava Chezar-Azerrad, CRTonline.org

COVID-19 patients may develop long-term cardiovascular complications, according to a new study from Germany that used cardiac magnetic resonance (CMR) imaging.

ACC Panel Provides Guidance for Cardiovascular Imaging in COVID-19 Patients

Jul 22, 2020 by
Brian C. Case, CRTonline.org

An expert panel from the American College of Cardiology (ACC) Cardiovascular Imaging Leadership Council provides suggestions for using multimodality imaging in evaluating cardiovascular complications in patients with COVID-19.

Total Stent Length, Post-Stent FFR Key Predictors of TVF at 2 Years Post-PCI, Study Shows

Jul 20, 2020 by
Charan Yerasi, CRTonline.org

Total stent length and post-stent fractional flow reserve (FFR) were the most important predictors of target vessel failure (TVF) at 2 years, according to study results released Monday.

TiNO-Coated Stents Noninferior at 12 Months, Superior at 18 Months to EES in Preventing MACE in ACS Patients

Jul 20, 2020 by
Giorgio A. Medranda, CRTonline.org

Cobalt-chromium-based titanium-nitride-oxide (TiNO)-coated stents were non-inferior to platinum-chromium-based biodegradable-polymer everolimus-eluting stents (EES) at 12 months and superior at 18 months with regard to major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS), according to study results released Monday.

THALES: Aspirin Plus Ticagrelor Lowers Risk of Death or Stroke vs. Aspirin Alone After Acute Ischemic Stroke or TIA

Jul 15, 2020 by
Giorgio A. Medranda, CRTonline.org

Aspirin with ticagrelor lowers the risk of the composite of death or stroke compared to aspirin alone in patients with mild to moderate acute non-cardioembolic ischemic stroke or transient ischemic attack (TIA), according to newly released results from a randomized, double-blind trial.

TAVR Predictive Simulation Shows Limited Effects on Operators’ Decisions

Jul 15, 2020 by
Jason Wermers, CRTonline.org

Software that performs predictive simulations of transcatheter aortic valve replacement (TAVR) for specific patients based on their clinical data did not change the operators’ choice of size of transcatheter heart valve (THV), but the simulation did inform the depth that operators implanted the valve, according to a prospective, observational study released Wednesday.

Administrative Claims Data Show Promise in Augmenting TAVR Trial Short-Term Outcomes, Survival

Jul 15, 2020 by
Brian C. Case, CRTonline.org

An analysis of administrative claims data demonstrates that they performed well in ascertaining death and short-term outcomes with procedural billing codes but performed more modestly in identifying other outcomes.

AHA Announces Online-Only Scientific Sessions

Jul 15, 2020 by
Jason Wermers, CRTonline.org

As the COVID-19 pandemic continues in the U.S. and globally, the American Heart Association (AHA) announced Wednesday that its annual Scientific Sessions will be held completely online.

FDA to Resume Domestic On-Site Inspections

Jul 15, 2020 by
CRTonline.org

The U.S. Food and Drug Administration is aiming to resume on-site inspections of FDA-regulated facilities beginning the week of July 20, the agency announced.

Jury Still Out on Hybrid Coronary Revascularization

Jul 13, 2020 by
Giorgio A. Medranda, CRTonline.org

Hybrid coronary revascularization (HCR), which combines coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), might offer the durability and long-term mortality benefit of a left internal mammary artery (LIMA) graft while maintaining a low-risk of immediate complications that accompany PCI, according to a study published Monday.

New Study Sheds Light on the Natural History of Patients With Aortic and Mitral Regurgitation

Jul 13, 2020 by
Brian Forrestal, CRTonline.org

Severe mitral regurgitation (MR) is common in patients with significant aortic regurgitation (AR) and that patients with multiple regurgitant lesions risk a 2.4-fold increase in the risk of death, according to a study published Monday.

Higher LP(a), CRP Levels Associated with Higher Risk of MACE, Analysis Shows

Jul 13, 2020 by
Charan Yerasi, CRTonline.org

A prespecified secondary analysis of the ACCELERATE trial shows that elevated levels of lipoprotein(a), or LP(a), and high-sensitivity C-reactive protein (hsCRP) >2mg/l are related to risk of cardiovascular death, myocardial infarction and stroke.

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