Blood pressure thresholds for ambulatory hypertension in African Americans have not been previously defined. Data from the Jackson Heart Study, a population-based cohort study comprising of 5306 African American Adults has suggested the following definitions for daytime, 24-hour, and night time daytime SBP/DBP ≥140/85 mm Hg, 24-hour SBP/DBP ≥135/80 mm Hg, and night time SBP/DBP ≥130/75 mm Hg.
The relationship between clonal hematopoiesis of indeterminate potential (CHIP) and coronary artery disease (CAD) has not been established. Data from 4726 patients with coronary artery disease and 3529 controls has indicated that CHIP carries a risk for CAD that is 1.9 times greater and 4.0 times greater for early onset myocardial infarction than non-carriers.
A number of studies have consistently reported that bioresorbable vascular scaffolds (BVS) are associated with an increased risk of stent thrombosis. The latest meta-analysis of 7 studies including 5,583 patients randomized to either BVS or an everolimus-eluting DES with a median follow-up of 2 years has concluded that BVS is associated with greater risk of target lesion failure and stent thrombosis across early, late, and very late periods.
The safety and efficacy of percutaneous alcohol septal ablation in young patients with obstructive hypertrophic cardiomyopathy has not been adequately studied. Data from 1,197 patients who were divided into young (≤50 years), middle-aged (51-64 years), and older (≥65 years) has indicated that 30-day mortality and pacemaker implantation rates are lower in the young. Annual adverse arrhythmic event rates were similar in the three age groups. Independent predictors of mortality in the young were age, female sex, and residual left ventricular outflow tract gradient.
The efficacy of bivalirudin, as compared to heparin, in STEMI patients has been doubtful. Data from the National Cardivascular Data Registry CathPCI database , examining the outcome of STEMI patients undergoing radial intervention, has indicated that bivalirudin is not associated with improvements in the composite endpoint of death, MI, or stroke when compared to heparin. Major bleeding rates were not significantly different.
The prognostic benefit of heart rate control in patients with heart failure with reduced ejection fraction in uncertain. A meta-analysis of 11 randomized studies has indicated that a higher heart rate at baseline in such patients was associated with greater mortality for patients in sinus rhythm but not in AF. Mortality was reduced in sinus rhythm patients randomised to beta blockers but not in AF patients. A lower resting heart rate, regardless of therapy, was associated with better prognosis for sinus rhythm patients.
Pearls From: William O'Neill, MD
Teva Announces Launch of Generic Zetia® in the United States
Saranas Closed $4 million to Advance New Device for Real-Time Detection of Active Bleeding During PCI
First Transcatheter Tricuspid Repair Subject with Trialign™ System Enrolled in Europe (SCOUT II Study)
Nicole Lou,Reporter, MedPage Today/CRTonline.org
June 23, 2017
June 16, 2017
Salynn Boyles, Contributing WriterJune 15, 2017
June 14, 2017
Crystal Phend, Senior Associate Editor, MedPage TodayJune 14, 2017
Crystal Phend, Senior Associate Editor, MedPage TodayJune 13, 2017
S Jaiswal, et al.; NEJM 2017 Online
E Lewis, et al.; AHJ 2017; 189:59-67
M Vaseghi, et al.; JACC 2017; 69:3070-80
S Sorrentino, et al.; JACC 2017; 69:3055-66
J Ravenell, et al.; Circ 2017; 135:2470-80
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