• New T2D, Heart Failure Statement; Varied Sleep & MetS; Chem Giants Sued Over PFAS

    News and commentary from the endocrinology world

    The American Heart Association and the Heart Failure Society of America released a joint scientific statement on management of type 2 diabetes and comorbid heart failure, including how to approach pharmacological and lifestyle modification therapies. (Circulation)

    Senseonics said the FDA approved "non-adjunctive" use of its Eversense 90-day continuous glucose monitoring system, meaning that patients don't have to confirm readings with fingersticks.

    Irregular sleep patterns were tied to the main components of metabolic syndrome, including obesity, hypertension, increase blood glucose, and high cholesterol. "Our research shows that, even after considering the amount of sleep a person gets and other lifestyle factors, every one-hour night-to-night difference in the time to bed or the duration of a night's sleep multiplies the adverse metabolic effect," said Tianyi Huang, ScD, of Brigham and Women's Hospital in Boston. (Diabetes Care)

    The FDA accepted Boehringer Ingelheim's and Eli Lilly's joint marketing application for their fixed-dose combination tablet comprising empagliflozin (Jardiance), linagliptin (Tradjenta) and metformin extended release indicated for adults with type 2 diabetes.

    Within 2 years of undergoing gastric bypass, half of patients had reoccurring acid reflux -- a lower rate than expected, "indicating that the treatment effect may have been overstated," study authors wrote. (Alimentary Pharmacology & Therapeutics)

    Childhood abuse or neglect was tied to more frequent vasomotor symptoms of menopause, including hot flashes. "Screening and counseling for trauma history, whether childhood trauma, intimate partner violence, or posttraumatic stress, should be part of routine preventive medical care for women at midlife and may be present in women with nighttime hot flashes," commented North American Menopause Society executive director JoAnn Pinkerton, MD. (Menopause)

    Some residents in Delaware are now suing the companies 3M, DuPont, and Chemours after their water supply was contaminated with high levels of perfluoroalkyl and polyfluoroalkyl substances (PFAS), types of endocrine-disrupting chemicals. (The New York Times)

    A gene variant may have evolved in humans to help protect against diabetes and high blood glucose -- but not all humans have the new version of the gene. (ScienceDaily)

    Wearing a medical alert bracelet or necklace was associated with a reduced risk of chronic kidney disease progressing to end-stage illness in a pilot study. (Clinical Journal of the American Society of Nephrology)

    Source:

    Read the original article on Medpage Today: New T2D, Heart Failure Statement; Varied Sleep & MetS; Chem Giants Sued Over PFAS

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