Cardiac arrest remains a significant global health challenge and is associated with higher morbidity and mortality. According to the Cardiac Arrest Registry to Enhance Survival, the incidence rate of out-of-hospital cardiac arrest (OHCA) is estimated to be 92.3 per 100,000 population and approximately 84 per 100,000 people based on European registries [ , ]. The latest data suggests that the survival rate to hospital discharge for OHCA is around 9.1 %, while the rate of good functional status at discharge is approximately 7.1 % [ ]. Over the years, significant efforts have been made to standardize and enhance care for post-resuscitation survival, including therapeutic hypothermia also known as Targeted Temperature Management (TTM), a promising approach to help reduce cerebral oxygen demand, metabolism, and prevent reperfusion injury [ , ].