<div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1585434786" paraeid="{00ab8161-b668-4952-9c26-57b37ec48b86}{233}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">In a sub-analysis of the CENTURY trial, researchers show w</span><span class="NormalTextRun SCXW206567046 BCX0">omen </span><span class="NormalTextRun SCXW206567046 BCX0">with coronary artery disease (CAD) </span><span class="NormalTextRun SCXW206567046 BCX0">have higher coronary blood flow (CBF) </span><span class="NormalTextRun SCXW206567046 BCX0">versus men with CAD despite similar lifestyles and underlying medical conditions.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1827500192" paraeid="{07ed1d66-7226-4079-9e12-ae25f4981f03}{231}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Women with CAD are also less likely to die, have PET perfusion defects, coronary calcification, heart attacks, </span><span class="NormalTextRun SCXW206567046 BCX0">revascularization</span><span class="NormalTextRun SCXW206567046 BCX0"> or major adverse cardiovascular events (MACE) compared with men.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1891150951" paraeid="{e6c64d36-39bc-419a-8a96-f38e50e562d7}{194}"><span class="NormalTextRun SCXW206567046 BCX0">The corresponding data were taken from the </span><a class="Hyperlink SCXW206567046 BCX0" href="https://clinicaltrials.gov/study/NCT00756379" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW206567046 BCX0" data-ccp-charstyle="Hyperlink">CENTURY trial</span></a><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0"> and reanalyzed by </span><span class="NormalTextRun SCXW206567046 BCX0">K. Lance Guld, MD, of the UTHealth Houston and Memorial Hermann Hospital, Texas, and colleagues, and published in </span></span><em><span class="NormalTextRun SCXW206567046 BCX0">JACC: Cardiovascular Imaging</span></em><span class="NormalTextRun SCXW206567046 BCX0"> this week.</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1226329755" paraeid="{1d3e8d45-6ff5-4cbb-9217-6ffda08f3b29}{239}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Women tend to develop CAD a couple </span><span class="NormalTextRun SCXW206567046 BCX0">decades</span><span class="NormalTextRun SCXW206567046 BCX0"> later than men who have similar cardiovascular risk factors. Little is known about the physiology behind this.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1327219045" paraeid="{0d8a3543-8a3c-478a-a88f-521843e8dfea}{217}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">The CENTURY trial (Comprehensive </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">LifEstyle</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">ModificatioN</span><span class="NormalTextRun SCXW206567046 BCX0">, Optimal Pharmacological Treatment and Utilizing PET Imaging for Quantifying and Managing Stable </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">CoronaRy</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">ArterY</span><span class="NormalTextRun SCXW206567046 BCX0"> Disease)</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SCXW206567046 BCX0">showed how lifestyle changes plus medical therapy, along with coronary flow capacity (CFC)-guided revascularization, significantly lowers the rate of all-cause death</span><span class="NormalTextRun SCXW206567046 BCX0">,</span><span class="NormalTextRun SCXW206567046 BCX0"> heart attack</span><span class="NormalTextRun SCXW206567046 BCX0">, revascularization and major adverse cardiac events (MACE) compared with standard care in patients with CAD.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1914379829" paraeid="{a3a6b50a-dc47-47c5-80cc-24de97d1e515}{113}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">This present analysis examined the sex differences in CBF</span><span class="NormalTextRun SCXW206567046 BCX0"> and coronary flow capacity</span><span class="NormalTextRun SCXW206567046 BCX0"> in patients with CAD. Positron emission tomography (PET) </span><span class="NormalTextRun SCXW206567046 BCX0">was used to measure the </span><span class="NormalTextRun SCXW206567046 BCX0">two </span><span class="NormalTextRun SCXW206567046 BCX0">variables.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1014427796" paraeid="{e1ab8b27-38d1-4195-8fa3-56e6bd5e3b3c}{233}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Clinical outcomes were recorded through 14 years of follow-up in the CENTURY trial. A total of 331 </span><span class="NormalTextRun SCXW206567046 BCX0">women (mean age=61.3 years; mean body mass index [BMI]=28.5;</span><span class="NormalTextRun SCXW206567046 BCX0"> history of hypertension=85.5%)</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SCXW206567046 BCX0">and 697 men</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SCXW206567046 BCX0">(mean age=61.3 years; mean BMI=29.1; history of hypertension=83.8%)</span><span class="NormalTextRun SCXW206567046 BCX0"> were re-analyzed in this present study.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="2113397741" paraeid="{5f8a3f21-4b33-41dc-89e9-e3820f60985e}{145}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Age, </span><span class="NormalTextRun SCXW206567046 BCX0">BMI</span><span class="NormalTextRun SCXW206567046 BCX0">, high blood pressure, </span><span class="NormalTextRun SCXW206567046 BCX0">diabetes</span><span class="NormalTextRun SCXW206567046 BCX0"> and cardiovascular risk scores were similar between men and women. </span><span class="NormalTextRun SCXW206567046 BCX0">Despite similar characteristics, women had lower coronary artery calcium, </span><span class="NormalTextRun SCXW206567046 BCX0">less severe </span><span class="NormalTextRun SCXW206567046 BCX0">CAD</span><span class="NormalTextRun SCXW206567046 BCX0"> and fewer defects in PET perfusion.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="293373153" paraeid="{44d46c8e-fe30-4bf7-8161-3394fc76f47f}{16}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Women had lower rates of all-cause mortality (log-rank p=0.0223), death or heart attack (log-rank p=0.0138), revascularization (log-rank p=0.0004</span><span class="NormalTextRun SCXW206567046 BCX0">)</span><span class="NormalTextRun SCXW206567046 BCX0"> and MACE (log-rank p<0.0001)</span><span class="NormalTextRun SCXW206567046 BCX0"> versus men.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="307411206" paraeid="{3121556f-e1b7-46c9-bcaf-b3a048d9ff05}{238}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">While some clinical indications were better in women compared with men, others were worse, such as rest and stress CBF (33% higher in women).</span><span class="NormalTextRun SCXW206567046 BCX0"> CBF was significantly higher in women and men with similar baseline health indicators.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1498514885" paraeid="{9984c219-8e8f-4f76-94d1-ac44ddbc264c}{141}"><span class="NormalTextRun SCXW206567046 BCX0">“When integrated with the published reports showing ∼10% smaller coronary arteries in women, these flow data suggest a potential global endothelial shear stress ∼82% higher in women than in men, suggesting a potential hypothetical chronic, diffuse, antiatherogenic differential mechanism,” the investigators in this study wrote.</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1357349720" paraeid="{a202e856-8e97-4cec-ba93-436c5e47d831}{57}"><span class="NormalTextRun SCXW206567046 BCX0">Overall, data from the CENTURY trial show that women with CAD experience higher CBF versus men with CAD, even when the sexes have comparable baseline characteristics.</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="288916130" paraeid="{4717bfd9-5dcd-4758-93e6-2aebcd63d85b}{184}"><span class="NormalTextRun SCXW206567046 BCX0">“This hypothesized femalespecific coronary architecture may also contribute to better outcomes than those observed in men with comparable risk-factor treatment, underscoring the imperative of maximally aggressive, sex-conscious preventive management to optimize cardiovascular outcomes in women,” the authors concluded.</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1629258359" paraeid="{9988818d-b5ff-4368-927a-2a04ff4f3795}{60}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">This study was sponsored by the </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">Weatherhead</span><span class="NormalTextRun SCXW206567046 BCX0"> Foundation and the </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">Weatherhead</span><span class="NormalTextRun SCXW206567046 BCX0"> Endowment at the University of Texas Health Science Center </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW206567046 BCX0">at</span><span class="NormalTextRun SCXW206567046 BCX0"> Houston.</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="21907287" paraeid="{e947c0f4-6307-4c2a-8a3c-eea41e09498f}{198}"><strong><span class="NormalTextRun SCXW206567046 BCX0">Source:</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="1334501338" paraeid="{0202ff77-5fc2-4d53-9d42-020d0b154920}{174}"><span class="NormalTextRun SCXW206567046 BCX0">Gould KL, Johnson NP, Roby AE, et al. Coronary blood flow in women from the CENTURY trial: Potential mechanisms for sex differences in coronary disease. </span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW206567046 BCX0"><em><span class="NormalTextRun SCXW206567046 BCX0">JACC: Cardiovasc </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">Imag</span></em><span class="NormalTextRun SCXW206567046 BCX0">. </span></span><span class="NormalTextRun SCXW206567046 BCX0">2026 September (Article in Press).</span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW206567046 BCX0"> <p class="Paragraph SCXW206567046 BCX0" lang="EN-US" paraid="103725314" paraeid="{0202ff77-5fc2-4d53-9d42-020d0b154920}{17}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW206567046 BCX0"><span class="NormalTextRun SCXW206567046 BCX0">Image Credit: </span><span class="NormalTextRun SpellingErrorV2Themed SCXW206567046 BCX0">Jirawatfoto</span><span class="NormalTextRun SCXW206567046 BCX0"> </span><span class="NormalTextRun SCXW206567046 BCX0">– stock.adobe.com</span></span><span class="EOP Selected SCXW206567046 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>