<div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1466660969" paraeid="{e48fdd95-efad-46b7-b3e2-7c4bd7d363b6}{173}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Women who undergo mitral transcatheter edge-to-edge repair (M-TEER) are more likely to be older and have worse symptoms compared with<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">men,</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>but<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">the two sexes<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">have similar outcomes at 6-months post-procedure, cardiologists say.</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="747757328" paraeid="{5ba9d85f-8ebf-4cef-a87d-8a72db376ebc}{109}"><span class="NormalTextRun SCXW163039804 BCX0">A study was published with these data online in<span> </span></span><em><span class="NormalTextRun SCXW163039804 BCX0">JACC: Advances</span></em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">—</span><span class="NormalTextRun SCXW163039804 BCX0">led by Reinhard J. Sauter, MD, of Heidelberg University, Mannheim, Germa</span><span class="NormalTextRun SCXW163039804 BCX0">ny,<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">and accompanied by colleagues from Germany,<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">China</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>and Switzerland—on Friday.</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="746310466" paraeid="{030e0b67-756a-47d6-a4fc-3243d02e4240}{27}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Women are less likely to undergo surgery for<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">primary</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>mitral regurgitation (MR)</span><span class="NormalTextRun SCXW163039804 BCX0">. Little is known about clinical differences after M-TEER in women versus men who have<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">severe MR.</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="547007782" paraeid="{f7b7d5fa-97e3-415d-9f27-39a3d3c67424}{204}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Investigators collected data from patients who underwent M-TEER<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">with the<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW163039804 BCX0">MitraClip</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>device (Abbott)<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">between May 2014 and October 2025 for this study.</span><span> </span><span class="NormalTextRun SCXW163039804 BCX0">The primary endpoint was death from any cause at 6-months post-procedure.</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="299677670" paraeid="{19d0f2a7-9c5e-415a-bf54-5b9e41d07bc5}{223}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Key secondary endpoints included reduced MR, rehospitalization for heart failure (HF)</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW163039804 BCX0"><span> </span>and</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>functional abilities (measured by the 6-minute walk test).</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="745278134" paraeid="{b30ba5a5-b408-450e-8cd4-b5f9014b29b7}{135}"><span class="NormalTextRun SCXW163039804 BCX0">A total of 293 patients were included in the study, and 40.6% of them were women. Both men and women had similar MR severity across the board. Men had higher rates of coronary artery disease (CAD) (81% in men vs 65% in women; p=0.002) and proportions of functional MR (47% in men, 37% in women).</span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1250643131" paraeid="{62a92763-c2d7-4c0d-bcf8-4c3dc8da4af2}{77}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Men and women had similar rates of death at 6-months follow-up (22% in men, 17% in women; p=0.301) as well as HF-related rehospitalization (10% in men, 13% in women; p=0.576</span><span class="NormalTextRun SCXW163039804 BCX0">).<span> </span></span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="541344637" paraeid="{ee8e1343-9c3b-4555-958b-7c25e3783fee}{158}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">W</span><span class="NormalTextRun SCXW163039804 BCX0">omen had lower<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">initial</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>functional capacity (p=0.001)</span><span class="NormalTextRun SCXW163039804 BCX0">,</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>but at 6-months, this was the same for men and women (p=0.778).</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>Women were also older than men at baseline (mean age=78.6 years versus 75.6 years).</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1693637512" paraeid="{049c03d7-1e58-41cd-99a0-c084b6e636da}{104}"><span class="NormalTextRun SCXW163039804 BCX0">Overall, women undergoing M-TEER for severe MR have worse functioning and older age at baseline compared with men, but the two sexes have similar 6-month outcomes.</span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1064215077" paraeid="{1604890f-6451-4d25-964f-38735a584170}{79}"><span class="NormalTextRun SCXW163039804 BCX0">“Thus, to optimize absolute functional recovery, increased clinical awareness and refined screening strategies for MR in women are warranted,” the investigators wrote.</span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1622326973" paraeid="{2369e8bd-9347-4425-b235-85b84231ab21}{74}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">“Future research should focus on whether sex-specific thresholds for intervention—accounting for smaller cardiac dimensions and differing etiological profiles—can<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">optimize</span><span class="NormalTextRun SCXW163039804 BCX0"><span> </span>the timing of treatment and further improve long-term outcomes in female patients.”</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1666528258" paraeid="{2369e8bd-9347-4425-b235-85b84231ab21}{114}"><strong><span class="NormalTextRun SCXW163039804 BCX0">Source:</span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="493437302" paraeid="{2369e8bd-9347-4425-b235-85b84231ab21}{198}"><span class="NormalTextRun SCXW163039804 BCX0">Sauter RJ, Schupp T, Sauter M, et al. Sex-based differences in outcomes after transcatheter edge-to-edge repair for severe mitral regurgitation.<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0"><em>JACC: Adv</em>.<span> </span></span><span class="NormalTextRun SCXW163039804 BCX0">2026 September 4.</span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW163039804 BCX0"> <p class="Paragraph SCXW163039804 BCX0" lang="EN-US" paraid="1563228142" paraeid="{415cba47-331f-4127-85ed-472cf326fc14}{130}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW163039804 BCX0"><span class="NormalTextRun SCXW163039804 BCX0">Image Credit: </span><span class="NormalTextRun SpellingErrorV2Themed SCXW163039804 BCX0">mojo_cp</span> <span class="NormalTextRun SCXW163039804 BCX0">– </span><span class="NormalTextRun SCXW163039804 BCX0">stock.adobe.com</span></span><span class="EOP Selected SCXW163039804 BCX0" data-ccp-props="{}"> </span></strong></p> </div>