<div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="450397538" paraeid="{54c18d2e-96c5-4b48-87b1-65c1a262b4c8}{79}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Thrombectomy<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">doesn’t</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>produce better clinical outcomes compared with medical therapy alone in patients with acute ischemic stroke (AIS) due to medium or distal vessel occlusions (MDVOS), data<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW236748022 BCX0">show</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>in the DISCOUNT trial.</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1470419860" paraeid="{1d83700e-66ac-474e-bf4a-5cd56b2505fa}{2}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Frédéric Clarençon, MD, PhD, of Sorbonne Université,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW236748022 BCX0">Pitié</span><span class="NormalTextRun SCXW236748022 BCX0">-Salpêtrière Hospital, Paris, and colleagues, reported these data in a manuscript published online in the<span> </span></span></span><span class="NormalTextRun SCXW236748022 BCX0"><em>Journal of the American Medical Association</em>.</span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1771989634" paraeid="{d087e496-b7ba-48b5-a1fc-299861e1b05f}{33}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Patients with AIS</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>and LVO</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>are often managed with mechanical thrombectomy. However, prior clinical trials usually ex</span><span class="NormalTextRun SCXW236748022 BCX0">clude patients with more distal occlusions</span><span class="NormalTextRun SCXW236748022 BCX0">.<span> </span></span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1735646886" paraeid="{17f3b482-cabb-4aa1-83df-65b8c573ab77}{207}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Investigators in this present analysis</span><span> </span><span class="NormalTextRun SCXW236748022 BCX0">— DISCOUNT, a multicenter, open-label,<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">randomized clinical trial</span><span class="NormalTextRun SCXW236748022 BCX0"> —</span><span> </span><span class="NormalTextRun SCXW236748022 BCX0">examined the clinical benefits of thrombectomy alongside medical treatment versus medical treatment alone in patients with AIS and medium or distal vessel occlusions (MDVO).<span> </span></span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1992538371" paraeid="{0d9684c6-83d8-4026-b073-f1a1c0afcd5a}{161}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">The rate of good clinical outcomes at 3-month follow-up —<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">a</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>m</span><span class="NormalTextRun SCXW236748022 BCX0">odified Rankin Scale</span><span class="NormalTextRun SCXW236748022 BCX0"> </span><span class="NormalTextRun SCXW236748022 BCX0">score of 0 to 2 — was the primary endpoint in this study.</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>An independent assessor, blinded to participant randomization,<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">evaluated the primary endpoint results.</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1553249900" paraeid="{993f9ee1-07fb-4f4d-8e39-439fbfed9c89}{115}"><span class="NormalTextRun SCXW236748022 BCX0">DISCOUNT took place across 22 stroke centers in France between November 2021 and April 2025.<span> </span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1613427719" paraeid="{6616b6bf-7434-4065-97be-f1cdbab55781}{122}"><span class="NormalTextRun SCXW236748022 BCX0">“Eligible adult patients had an AIS due to a primary MDVO within 8 hours of symptom onset or within 24 hours of last seen well if no hyperintense signal was present on fluid-attenuated inversion recovery imaging,” the authors wrote.</span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1156563108" paraeid="{2cf8ab58-4360-4d1e-a7b1-eacb55f4ab4b}{28}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">A total of<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">244 patients<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">(median age=75 years; 56% male)<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">were randomized<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">1:1<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">to receive thrombectomy plus medical treatment (n=123) or medical therapy alone (n=121).<span> </span></span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1488020695" paraeid="{9c365f52-7a2a-41b5-a9b2-562962010a6e}{141}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Of the patients in the thrombectomy group,<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">81% underwent<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">thrombectomy,</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>and no patients in the medical therapy group received thrombectomy. Across both groups, 89% completed follow-up.</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="480630020" paraeid="{d087e496-b7ba-48b5-a1fc-299861e1b05f}{27}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">At 3-</span><span class="NormalTextRun SCXW236748022 BCX0">month</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>follow-up, 62% of patients in the thrombectomy group and 68% of patients in the medical therapy group had good clinical outcomes (odds ratio=0.73, 95% confidence interval [CI]=0.40-1.31</span><span class="NormalTextRun SCXW236748022 BCX0">; p=0.29).</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="77271521" paraeid="{9bf03643-2f0e-4a8a-b07a-ce44c40ea1ad}{145}"><span class="NormalTextRun SCXW236748022 BCX0">Patients in the thrombectomy group had significantly higher rates of intracranial hemorrhage (11% versus 3%; p<0.001) and embolus migration (5% versus 1%; p=0.04). Mortality was similar in both groups (6% versus 8%; p=0.49).</span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="1883515104" paraeid="{bd174f79-59b1-4143-8ab0-2103f1e81fb0}{135}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Results from the DISCOUNT study<span> </span></span><span class="NormalTextRun SCXW236748022 BCX0">indicate</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>that thrombectomy in patients with AIS due to a primary MDVO does not lead to better clinical outcomes compared with medical therapy alone.</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="381799481" paraeid="{54c18d2e-96c5-4b48-87b1-65c1a262b4c8}{18}"><strong><span class="NormalTextRun SCXW236748022 BCX0">Source:</span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="357154673" paraeid="{54c18d2e-96c5-4b48-87b1-65c1a262b4c8}{55}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW236748022 BCX0"><span class="NormalTextRun SpellingErrorV2Themed SCXW236748022 BCX0">Clarençon</span><span class="NormalTextRun SCXW236748022 BCX0"><span> </span>F, Bala F, Baptiste A, et al. Mechanical thrombectomy in ischemic stroke with a medium or a distal arterial occlusion: The DISCOUNT randomized clinical trial.<span> </span></span></span><em><span class="NormalTextRun SCXW236748022 BCX0">J Am Med Assoc</span></em><span class="NormalTextRun SCXW236748022 BCX0">. 2026 July 24 (Article in Press).</span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW236748022 BCX0"> <p class="Paragraph SCXW236748022 BCX0" lang="EN-US" paraid="2007929054" paraeid="{6d91c110-fb99-45c8-a28d-c6cfaa654419}{215}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW236748022 BCX0"><span class="NormalTextRun SCXW236748022 BCX0">Image Credit: </span><span class="NormalTextRun SCXW236748022 BCX0">MQ-</span><span class="NormalTextRun SCXW236748022 BCX0">Illustrations</span> <span class="NormalTextRun SCXW236748022 BCX0">– stock.adobe.com</span></span><span class="EOP Selected SCXW236748022 BCX0" data-ccp-props="{}"> </span></strong></p> </div>