<div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="308288662" paraeid="{09ed9c77-a147-4eb9-8459-807eb1b22990}{168}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Valvular heart disease (</span><span class="NormalTextRun SCXW255642586 BCX8">VHD</span><span class="NormalTextRun SCXW255642586 BCX8">)</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>is<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">widespread,</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>and<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">the number</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>of patients with VHD</span><span> </span><span class="NormalTextRun SCXW255642586 BCX8">is</span><span class="NormalTextRun SCXW255642586 BCX8"> growing</span><span class="NormalTextRun SCXW255642586 BCX8">, heart experts say as they weigh in on the prevalence of VHD in older adults across the U.S.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="126090695" paraeid="{880b6c40-9a38-47d6-9bfa-aa4c84f2d8eb}{198}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Data from the PREVUE-VALVE trial show that tricuspid regurgitation is the most common VHD<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">among older<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">Americans.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1970068590" paraeid="{412efc86-e8b6-4a11-9c5a-f4e6de52cf76}{240}"><span class="NormalTextRun SCXW255642586 BCX8">Michael I. Brener, MD, MS, of the Columbia University Irving Medical Center, New York, and colleagues, reported the corresponding data in a manuscript published online Tuesday in the<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8"><em>Journal of the American College of Cardiology</em>.</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1225267086" paraeid="{0da33273-482d-40d9-aaf9-14f6c7d45b79}{158}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">VHD is a significant health condition, and<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">the prevalence of VHD is increasing in the U.S</span><span class="NormalTextRun SCXW255642586 BCX8">. Despite the growing body of </span><span class="NormalTextRun SCXW255642586 BCX8">research</span><span class="NormalTextRun SCXW255642586 BCX8"> and technologies available for treating VHD, such as surgical and transc</span><span class="NormalTextRun SCXW255642586 BCX8">atheter interventions,<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">some disadvantaged populations may be underdiagnosed and undertreated.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="414389923" paraeid="{8b133b40-b61b-4fa9-b7a9-c704072a66e7}{191}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Prior </span><span class="NormalTextRun SCXW255642586 BCX8">clinical studies</span><span class="NormalTextRun SCXW255642586 BCX8"> reported<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">statistics on the rates of VHD in the U.S., but these data were limited to cohorts that lacked diversity and were not representative of the entire U.S. population.</span><span class="NormalTextRun SCXW255642586 BCX8"> The most underrepresented populations include women, older<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">patients</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>and minorities.<span> </span></span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="966437731" paraeid="{0e9ab9a8-d90a-49b7-9ad7-8b47b872989b}{126}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Patients in other clinical studies were also evaluated based on outdated echocardiographic technologies</span><span class="NormalTextRun SCXW255642586 BCX8">, the investigators noted.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="825366535" paraeid="{57a6f6fc-59c3-443c-94dc-900a9ce3bddd}{171}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Data in this present analysis were collected from a decentralized</span><span class="NormalTextRun SCXW255642586 BCX8">, prospective</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>study of older adults</span><span class="NormalTextRun SCXW255642586 BCX8">:</span><span class="NormalTextRun SCXW255642586 BCX8"> </span></span><a class="Hyperlink SCXW255642586 BCX8" href="https://clinicaltrials.gov/study/NCT05357404" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW255642586 BCX8" data-ccp-charstyle="Hyperlink">PREVUE-VALVE</span></a><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>(Age and Sex-Specific<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">PREValence</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>of<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">AcqUirEd</span><span> </span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">VALVular</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>Heart<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">DiseasE</span><span class="NormalTextRun SCXW255642586 BCX8">)</span><span class="NormalTextRun SCXW255642586 BCX8">.<span> </span></span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1491671821" paraeid="{d0a68db8-cd51-422e-851d-c1d7e10ce842}{41}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Individuals aged 65 to 85 years were randomly selected</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>between April 2022 an</span><span class="NormalTextRun SCXW255642586 BCX8">d</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>April 2025</span><span class="NormalTextRun SCXW255642586 BCX8">: data<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">came from filled prescriptions at a CVS or Walgreens pharmacy</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>across all 50 states in the U.S.</span><span class="NormalTextRun SCXW255642586 BCX8">, and individuals were then contacted via e-mail, snail mail or text with an invitation to be part of the study.</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>Zip codes and demographic data were used to<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">identify</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>candidates.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="2076678120" paraeid="{1f1025bb-b90d-4ee0-ab4c-f19b1b73e741}{238}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Procedures were all completed at participants’ homes, including a comprehensive transthoracic echocardiogram.</span><span> </span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1435129250" paraeid="{6648e1d9-a3b3-425b-ab58-f020198035ae}{75}"><span class="NormalTextRun SCXW255642586 BCX8">“</span><span class="NormalTextRun SCXW255642586 BCX8">By bringing the clinical research apparatus directly to the participant, we bypassed many traditional barriers to recruitment and enrolled a cohort that was broadly representative of the U.S. population, while still adhering to rigorous standards for data collection and processing,” the authors wrote.</span><span class="EOP SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1834955920" paraeid="{cbbdfadc-ddbb-4c21-879c-606337d9fc82}{174}"><span class="NormalTextRun SCXW255642586 BCX8">Moderate or greater VHD, weighted to be inclusive of the U.S. population, was the primary outcome in this study. Additionally, the prevalence of clinically significant VHD, including mild-to-moderate regurgitant disease, was the co-primary endpoint.</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="2139893540" paraeid="{95dc80bd-edc2-4a2f-b969-6d3213dd213c}{94}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">The study coordinators contacted a total of 662,880 individuals, and 8,290 of them opened the study portal. Eventually, 3,394 completed the study forms, and 3,002 completed all study procedures.<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">Two participants were excluded due to<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW255642586 BCX8">uninterpretable</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>echocardiograms.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="978047443" paraeid="{56618115-47d7-47e2-bc11-a2908fc7dd44}{225}"><strong><span class="NormalTextRun SCXW255642586 BCX8">Study results</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="875469330" paraeid="{022d7ae1-c526-4115-9145-6f06da406471}{244}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">A total of 3,000 individuals were evaluated (median age=71 years; 57.1% female; 14.6% non-Hispanic Black, 9.4% Hispanic).</span><span> </span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1048320071" paraeid="{a8ae9fe4-ef95-4aaf-af5d-5939398aa26d}{236}"><span class="NormalTextRun SCXW255642586 BCX8">Greater than or moderate VHD was present in 8.2% of participants, and this increased to 18.4% for clinically significant VHD.</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="575581394" paraeid="{e9c867a3-46cd-4d0a-a219-4ad83f007710}{190}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">The most common conditions were, in order from most prevalent to least, tricuspid regurgitation, aortic stenosis, mitral regurgitation, aortic<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW255642586 BCX8">regurgitation</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>and mitral stenosis.<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">Participants who were older were more likely to have<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW255642586 BCX8">VHD</span><span class="NormalTextRun SCXW255642586 BCX8">. This was not<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">impacted</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>by sex.<span> </span></span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1795414384" paraeid="{fb1be63d-50a0-4a5a-871d-3454bd09b75f}{154}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">When adjusting for age and sex, the researchers found that non-Hispanic Bl</span><span class="NormalTextRun SCXW255642586 BCX8">ack patients had lower rates of VHD compared with non-Hispanic White patients. This was seen mostly in lower rates of aortic stenosis and regurgitation.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="2125525020" paraeid="{d2c512ed-0958-4090-84d7-8c71fb09a2be}{143}"><span class="NormalTextRun SCXW255642586 BCX8">No significant differences were found between Hispanic and non-Hispanic participants.</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1901417713" paraeid="{35cfbbe7-3cde-47de-b6a1-bf68aaf2ac8d}{177}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">When these data are applied to the U.S. population,<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">roughly 4.7</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>million 65–85-year-olds have greater than or moderate VHD, and<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">10.6 million people</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>have clinically significant VHD.</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>The investigators noted that these numbers will<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">likely increase</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>to 6.5 and 14.7 million by 2060.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="783558287" paraeid="{b89c3b02-8ca6-4232-872d-f5067da33c55}{38}"><strong><span class="NormalTextRun SCXW255642586 BCX8">National impact</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="616861453" paraeid="{a68bfa1b-2341-4fda-aaec-78cf7995837a}{202}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">In an accompanying editorial, Rick A. Nishimura, MD, and Carole A. Warnes, MD, both from the Mayo Clinic in Rochester, Minnesota, wrote about high-</span><span class="NormalTextRun SCXW255642586 BCX8">risk populations in VHD and the advances in treatment for VHD since the late 1990s.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1981595039" paraeid="{6c7cbfa5-d575-4788-a953-151bb5294ab5}{208}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">The editorialists commended Brener et al. for a “novel” model to<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">determine</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>the rate of VHD in older individuals across the U.S.</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>They also acknowledged the importance of clinicians continued progress in management strategies for tricuspid regurgitation, given that it was the most common VHD in this present study.</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1728596076" paraeid="{eef2902c-4d89-4b59-ab6a-4bee63c6c91e}{12}"><span class="NormalTextRun SCXW255642586 BCX8">“The authors should be congratulated on this unique population study that avoids much selection bias, bypasses the traditional health care infrastructure, and facilitates patient participation by taking the evaluation directly to the home,” the editorialists concluded.</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="791440851" paraeid="{a4ca4f34-a935-44d2-9439-4db4e12c67f2}{97}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">“Although no sampling strategy is perfect, this approach<span> </span></span><span class="NormalTextRun SCXW255642586 BCX8">likely represents</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>the closest national approximation we have to date and meaningfully improves on prior registry-based and convenience samples.”</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1103053717" paraeid="{a4ca4f34-a935-44d2-9439-4db4e12c67f2}{143}"><strong><span class="NormalTextRun SCXW255642586 BCX8">Sources:</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1630126597" paraeid="{6648e1d9-a3b3-425b-ab58-f020198035ae}{17}"><span class="NormalTextRun SCXW255642586 BCX8">Brener MI, Chuang ML, Nishimura R, et al. Population prevalence of valvular heart disease in the United States: The PREVUE-VALVE study.<span> </span></span><em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">J Am Coll </span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">Cardiol</span></span></em><span class="NormalTextRun SCXW255642586 BCX8">. 2026 June 16 (Article in Press).</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1105024219" paraeid="{a4ca4f34-a935-44d2-9439-4db4e12c67f2}{200}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Nishimura RA, Warnes CA. Helping<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW255642586 BCX8">our patients</span><span class="NormalTextRun SCXW255642586 BCX8"><span> </span>with valvular heart disease: A call to action.<em> </em></span></span><em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">J Am Coll </span><span class="NormalTextRun SpellingErrorV2Themed SCXW255642586 BCX8">Cardiol</span></span></em><span class="NormalTextRun SCXW255642586 BCX8">. 2026 June 16 (Article in Press).</span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW255642586 BCX8"> <p class="Paragraph SCXW255642586 BCX8" lang="EN-US" paraid="1008678304" paraeid="{b00400ed-e662-47df-b476-918f6cf7f46c}{184}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW255642586 BCX8"><span class="NormalTextRun SCXW255642586 BCX8">Image Credit: </span><span class="NormalTextRun SCXW255642586 BCX8">Atlas</span><span class="NormalTextRun SCXW255642586 BCX8"> – stock.adobe.com</span></span><span class="EOP Selected SCXW255642586 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>