<div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1457685553" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{13}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">A new study<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">reveals a</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>link between<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">intensive lifestyle<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">intervention and</span></span><span> </span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">a lower long-term risk of multimorbidity in adults with prediabetes,</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>with researchers noting that<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">metformin show</span><span class="NormalTextRun SCXW209445441 BCX0">s</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>no significant benefit compared with placebo</span><span class="NormalTextRun SCXW209445441 BCX0">.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="566004842" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{15}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">The 21-year follow-up analysis included 1,173 adults enrolled in Medicare.</span><span> </span><span class="NormalTextRun SCXW209445441 BCX0">All had originally taken part in the Diabetes Prevention Program and later the Diabetes Prevention Program Outcomes Study.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1594464009" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{17}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">By the end of follow-up, 82% of participants in the lifestyle group had developed at least two chronic conditions. This<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW209445441 BCX0">compared</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>with 85% in the metformin group and 87% in the placebo group.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1761235254" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{19}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">“</span><span class="NormalTextRun SCXW209445441 BCX0">Among adults with prediabetes at baseline, lifestyle intervention, but not metformin, was associated with a lower burden of multimorbidity</span><span class="NormalTextRun SCXW209445441 BCX0">,”<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">wrote</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>the research team, led by<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">Marcel E. Salive, MD</span><span class="NormalTextRun SCXW209445441 BCX0">, from the<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">National Institute on Agin</span><span class="NormalTextRun SCXW209445441 BCX0">g in</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>Bethesda, Maryland.</span><span> </span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" lang="EN-US" paraid="91911917" paraeid="{8321418f-6eaf-43ea-9e88-1234e67323fe}{75}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">“</span><span class="NormalTextRun SCXW209445441 BCX0">Lifestyle programs may persistently lower the development of chronic conditions.”</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1159646178" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{21}"><strong><span class="NormalTextRun SCXW209445441 BCX0">Adjusted findings</span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1640133848" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{23}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">After adjustment for relevant covariates,<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">the team noted that<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">lifestyle intervention was associated with a 21% lower risk of multimorbidity compared with placebo (hazard ratio</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>[HR]</span><span class="NormalTextRun SCXW209445441 BCX0">, 0.79; 95%<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">confidence interval [CI]</span><span class="NormalTextRun SCXW209445441 BCX0">, 0.68–0.93). Metformin was not significantly different from placebo (HR, 0.91; 95% CI, 0.78–1.07).</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="80445018" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{25}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">Further f</span><span class="NormalTextRun SCXW209445441 BCX0">indings remained consistent when diabetes was removed from the multimorbidity definition, suggesting the lifestyle intervention’s association with reduced chronic disease burden was not solely explained by diabetes prevention.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="674477115" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{27}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">The lifestyle group also showed lower risk when the analysis focused on more severe disease accumulation. Compared with placebo, lifestyle intervention was associated with a 25% lower risk of developing three chronic conditions and a 43% lower risk of developing high-cost condition dyads, such as combinations involving stroke, chronic kidney disease, chronic obstructive pulmonary<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">disease</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>or heart failure.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="799871816" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{29}"><span class="NormalTextRun SCXW209445441 BCX0">The authors said the results extend the known benefits of lifestyle intervention beyond diabetes prevention. They noted that more than 20 years after the original intervention, most participants had developed multiple chronic conditions, underlining the scale of disease burden in older adults with a history of prediabetes.</span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="284430696" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{31}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">Beyond </span><span class="NormalTextRun SCXW209445441 BCX0">d</span><span class="NormalTextRun SCXW209445441 BCX0">iabetes</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="783625905" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{33}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">“Beyond diabetes prevention, lifestyle intervention was associated with fewer chronic conditions in aging</span><span class="NormalTextRun SCXW209445441 BCX0">,” wrote the researchers.<span> </span></span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" lang="EN-US" paraid="2131956135" paraeid="{8321418f-6eaf-43ea-9e88-1234e67323fe}{101}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">“</span><span class="NormalTextRun SCXW209445441 BCX0">However, randomization to metformin was not associated with a difference in multimorbidity from placebo.”</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1553658010" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{35}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">In an accompanying editorial, Hermes Florez, MD, PhD, MPH, MA, and Caroline Foster, PhD, from the Medical University of South Carolina in Charleston, and Gilberto Vizcaino, MD, PhD, from Universidad<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0">del Zulia in Maracaibo, Venezuela, reemphasized</span><span> </span><span class="NormalTextRun SCXW209445441 BCX0">the role of lifestyle intervention in reducing the growing burden of diabetes-related multimorbidity.</span></span><span class="NormalTextRun SCXW209445441 BCX0"> </span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1683675342" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{37}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">The authors noted that diabetes and prediabetes remain</span><span class="NormalTextRun SCXW209445441 BCX0">ed</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>major public health challenges, with millions of older adults at risk of developing multiple chronic conditions.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1062238536" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{39}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">Editorial </span><span class="NormalTextRun SCXW209445441 BCX0">c</span><span class="NormalTextRun SCXW209445441 BCX0">ontext</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1178424907" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{41}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">The</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>editorialists</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>also noted that lifestyle interventions may offer benefits beyond diabetes prevention, while pharmacologic approaches, including GLP-1 receptor agonists and tirzepatide, remain areas of active research for reducing multimorbidity burden.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="403635814" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{43}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">“Modest weight loss through healthy nutrition and increased physical activity remains a cornerstone to preserve quality of life and to potentially promote healthy longevity in this population</span><span class="NormalTextRun SCXW209445441 BCX0">,</span><span class="NormalTextRun SCXW209445441 BCX0">”</span><span> </span><span class="NormalTextRun SCXW209445441 BCX0">they</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>c</span><span class="NormalTextRun SCXW209445441 BCX0">oncluded.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="1597356532" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{45}"><strong><span class="NormalTextRun SCXW209445441 BCX0">Sources:</span></strong><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="9404702" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{48}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SpellingErrorV2Themed SCXW209445441 BCX0">Salive</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>ME, Tjaden AH, Ames JR, et al. Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW209445441 BCX0">With</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>Prediabetes.<span> </span></span></span><em><span class="NormalTextRun SCXW209445441 BCX0">JAMA</span></em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">. 2026</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>June 15 (Article in Press)</span><span class="NormalTextRun SCXW209445441 BCX0">. </span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" paraid="347574856" paraeid="{f0ff89a3-24bb-41fe-af1f-a8649413ae65}{50}"><span class="NormalTextRun SCXW209445441 BCX0">Florez H, Foster C, Vizcaino G. Addressing Multimorbidity Challenges in Diabetes—Lifestyle and Beyond.<span> </span></span><span class="NormalTextRun SCXW209445441 BCX0"><em>JAMA</em>.</span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>2026</span><span class="NormalTextRun SCXW209445441 BCX0"><span> </span>June 15 (Article in Press)</span><span class="NormalTextRun SCXW209445441 BCX0">.</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> </div> <div class="OutlineElement Ltr SCXW209445441 BCX0"> <p class="Paragraph SCXW209445441 BCX0" lang="EN-US" paraid="14212399" paraeid="{19d0b842-94fa-4a95-94f1-eb2f00c222a5}{37}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW209445441 BCX0"><span class="NormalTextRun SCXW209445441 BCX0">Image Credit: </span><span class="NormalTextRun SCXW209445441 BCX0">udra11 </span><span class="NormalTextRun SCXW209445441 BCX0">– stock.adobe.com</span></span><span class="EOP Selected SCXW209445441 BCX0" data-ccp-props="{"335551550":6,"335551620":6}"> </span></strong></p> </div>