<div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="196300180" paraeid="{dae57a21-1838-4e51-8896-82160af688ce}{86}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">New research shows that e</span><span class="NormalTextRun SCXW15196009 BCX0">arly hemodynamic valve deterioration (HVD)<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">causes adverse events and clinical outcomes after transcatheter aortic valve implantation (TAVI)</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>and can be a prognostic indicator for patients undergoing the procedure.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" paraid="249309288" paraeid="{1af386de-7733-4807-b54e-76254e65b629}{10}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">Antonin Trimaille, MD, PhD,<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">of the Quebec Heart</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>& Lung Institute, Laval University, Canada, and Strasbourg University Hospital, France,<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">presented these results on Thursday during a Hotline late-breaking clinical trial session at the<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW15196009 BCX0">EuroPCR</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>2026 Congress in Paris.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> The data were simultaneously published in <em>Eurointervention</em>.</span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="163155651" paraeid="{e9aa8389-486b-4ed4-a891-8dca0508035d}{28}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">Small studies have<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">demonstrated</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>the poor outcomes associated with HVD after TAVI, but data from larger studies are lacking.<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">The investigators in this analysis examined the impact of HVD on patients undergoing TAVI in a larger population.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="838608325" paraeid="{ef340609-0e96-4721-86ab-6c83ad31f188}{109}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">The investigators used d</span><span class="NormalTextRun SCXW15196009 BCX0">ata from an international, multicenter registry</span><span class="NormalTextRun SCXW15196009 BCX0">, including patients across<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">medical centers in Canada, Spain,<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">France</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>and Italy who</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>under</span><span class="NormalTextRun SCXW15196009 BCX0">went</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>TAVI</span><span class="NormalTextRun SCXW15196009 BCX0">.<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">A mean transaortic gradient of ≥<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">10 mm</span><span class="NormalTextRun SCXW15196009 BCX0">Hg</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>on echocardiography, versus discharge echocardiography,</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>was the definition of early HVD in these patients.</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>Data were collected between 2007 and 2025.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="1005797913" paraeid="{dc2fe7f8-0156-4aea-a3d4-d50fe3ad76bf}{247}"><span class="NormalTextRun SCXW15196009 BCX0">Valve-related long-term clinical efficacy, rated by the Valve Academic Research Consortium 3, was the primary outcome.</span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="1167840002" paraeid="{5b7f4ed3-fa63-4d90-8fcf-fb0d130b76ae}{141}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">The analysis included a total of 7,392 patients</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>(mean age=81 years, 48.1% female, average<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">body mass index [</span><span class="NormalTextRun SCXW15196009 BCX0">BMI</span><span class="NormalTextRun SCXW15196009 BCX0">]=27.7)</span><span class="NormalTextRun SCXW15196009 BCX0">. Of these patients, 231 had HVD (3.1%).<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">The investigators found that</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>BMI<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">increase</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>(p=0.021)</span><span class="NormalTextRun SCXW15196009 BCX0">, prosthesis size <<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">26 mm</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>(p<0.001)</span><span class="NormalTextRun SCXW15196009 BCX0">,</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>valve-in-valve procedure</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>(p<0.001</span><span class="NormalTextRun SCXW15196009 BCX0">)</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>and no anticoa</span><span class="NormalTextRun SCXW15196009 BCX0">gulation at discharge<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">(p<0.001)<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">all independently predicted early HVD.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="874714981" paraeid="{34af630b-f962-44ef-8742-3e30c4b34847}{11}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">At the median 4-year follow-up, early HVD<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">created<span> </span></span><span class="NormalTextRun SCXW15196009 BCX0">worse</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>long-term clinical efficacy and a higher risk of stroke, as well as higher risk of stage 2 or 3 bioprosthetic valve dysfunction</span><span class="NormalTextRun SCXW15196009 BCX0"><span> </span>and bioprosthetic valve failure.</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="1314094774" paraeid="{46b1ffac-1052-448b-a2cd-3fb8f7c0189e}{57}"><span class="NormalTextRun SCXW15196009 BCX0">These findings were also seen in a propensity score-matched cohort as well as sensitivity analysis.</span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="973913041" paraeid="{9d89df4c-846c-4cfd-aa73-94a5c6b1617c}{14}"><span class="NormalTextRun SCXW15196009 BCX0">In a PCR press conference on Tuesday, Dr. Trimaille concluded that patients with early HVD are more likely to have worse clinical and valve-related outcomes.</span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="592667274" paraeid="{1a8c8b33-34ec-4cdb-9a81-3ccadf3ac703}{98}"><span class="NormalTextRun SCXW15196009 BCX0">“These findings support early post-TAVI surveillance, including echocardiographic followup within 3 months,” Dr. Trimaille said.</span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="1321507248" paraeid="{5658b058-b363-4fb0-a0f9-450b5c385c15}{44}"><span class="NormalTextRun SCXW15196009 BCX0">“Given the suspected thrombotic mechanism, further studies should confirm this link and define optimal management, potentially including systematic CT and anticoagulation in case of early HVD.”</span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW15196009 BCX0"> <p class="Paragraph SCXW15196009 BCX0" lang="EN-US" paraid="746835753" paraeid="{b4673e4c-100c-40e7-80fb-5f75e5c535bb}{72}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW15196009 BCX0"><span class="NormalTextRun SCXW15196009 BCX0">Image Credit: </span><span class="NormalTextRun SCXW15196009 BCX0">resul</span><span class="NormalTextRun SCXW15196009 BCX0"> – stock.adobe.com</span></span><span class="EOP SCXW15196009 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>