<div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="971860898" paraeid="{bc584d8d-6b41-4171-9e7c-cdfe01f8cbfc}{138}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Men and women have similar mortality rates<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">and mitral regurgitation (MR) reduction<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">1-year after mitral valve transcatheter edge-to-edge repair (M-TEER) with the<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">PASCAL<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">system</span><span class="NormalTextRun SCXW167272092 BCX8">, data from the REPAIR study show.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="2043871860" paraeid="{040dc937-72fb-4d0a-9fee-c3534586d871}{55}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">However, women have<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">optimal</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>results from M-TEER less<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">frequently</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>than men because of higher postprocedural gradients, the investigators noted.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1657298120" paraeid="{b56d93f9-6a0c-4e5c-b2e0-1bd997ec4569}{173}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">The results from the REPAIR trial were reported by Philipp von Stein, MD, of the Heart Center of the University of Cologne, Germany, and colleagues from</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>the U.S. and Europe, in a manuscript published online Wednesday in<span> </span></span></span><span class="NormalTextRun SCXW167272092 BCX8">JACC: Advances</span><span class="NormalTextRun SCXW167272092 BCX8">.</span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1111847771" paraeid="{c1a069dc-5988-4d96-978e-1cef06006772}{30}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Patients with<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">MR</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>who are at<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">high risk</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>for surgery<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">often und</span><span class="NormalTextRun SCXW167272092 BCX8">ergo M-TEER. Little is known about sex-specific M-TEER outcomes</span><span class="NormalTextRun SCXW167272092 BCX8">, especially</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>with the<span> </span></span></span><a class="Hyperlink SCXW167272092 BCX8" href="https://www.edwards.com/healthcare-professionals/products-services/transcatheter-mitral-tricuspid-technologies/pascal-precision-system" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-US" lang="EN-US" class="TextRun Underlined SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8" data-ccp-charstyle="Hyperlink">PASCAL<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8" data-ccp-charstyle="Hyperlink">precision<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8" data-ccp-charstyle="Hyperlink">system</span></span></a><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>(Edwards Lifesciences</span><span class="NormalTextRun SCXW167272092 BCX8">)</span><span class="NormalTextRun SCXW167272092 BCX8">.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="984383492" paraeid="{30d0c5e3-fc1e-4393-b4d7-0affd07ae871}{167}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Investigators in this multicenter, investigator-initiated</span><span class="NormalTextRun SCXW167272092 BCX8">, observational</span><span class="NormalTextRun SCXW167272092 BCX8"> study<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">utilized</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>data from the </span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">REgistry</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>of<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">PAscal</span><span> </span><span class="NormalTextRun SCXW167272092 BCX8">for<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">mItral</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>Regurgitation (REPAIR).<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">Patients were treated across 14<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">medical</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>centers with the<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">PASCAL</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>M-TEER system between 2019 and 2024.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="101296589" paraeid="{5d194653-90a0-451b-a959-f95de200e0eb}{61}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Optimal result<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">(residual MR ≤ 1+ and mean<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">transmitral</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>pressure gradient <<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">5<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">mm</span><span class="NormalTextRun SCXW167272092 BCX8">Hg)</span><span> </span><span class="NormalTextRun SCXW167272092 BCX8">at</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>hospital discharge was the primary outcome in this trial. Additionally,<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">the researchers</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>examined Mitral Valve Academic Research Consortium-defined technical success and al</span><span class="NormalTextRun SCXW167272092 BCX8">l-cause death at 1-year post-procedure.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="57203548" paraeid="{ace0553d-c632-4a1f-9d18-20347a9abbc3}{229}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">A total of 2,601 patients were included in the REPAIR trial (44.2% women).<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">Women were, on average, older than the men in the trial (mean age women=81.0 years; mean age men=79.8 years; p<0.001).</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>Men had a higher average body mass index (BMI) (25.2) versus women (24.7; p<0.001).</span><span class="NormalTextRun SCXW167272092 BCX8"> </span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="776423834" paraeid="{13fc2fce-76ff-4465-89c9-12e167706375}{200}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">The median follow-up time was<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">449 days</span><span class="NormalTextRun SCXW167272092 BCX8">.</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>Common comorbidities included arterial hypertension (men=82.3%, women=84.9%), diabetes mellitus (men=25.8%, women=20.0%), coronary artery disease (</span><span class="NormalTextRun SCXW167272092 BCX8">men=67.1%, women=49.1%) and atrial fibrillation (men=71.4%, women=71.1%).</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1411754412" paraeid="{ee7d5529-c6ce-444c-a828-6d72ec520fc5}{135}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Women and men</span><span class="NormalTextRun SCXW167272092 BCX8"> had similar MR etiologies (primary= 33.5%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>in women</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>vs 32.4%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>in men</span><span class="NormalTextRun SCXW167272092 BCX8">; secondary= 48.9%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>in women</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>vs 52.1</span><span class="NormalTextRun SCXW167272092 BCX8">%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>in men</span><span class="NormalTextRun SCXW167272092 BCX8">; mixed= 17.6%<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">in women<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">vs 15.6%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>in men</span><span class="NormalTextRun SCXW167272092 BCX8">; p=0.219).</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1759233997" paraeid="{debcd31a-63c1-4a1d-b5ea-0546f7fd39d6}{72}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Both men and women had high technical success during M-TEER (97.0% vs 97.7%, p=0.395), but men had more<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">optimal</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>results than women (</span><span class="NormalTextRun SCXW167272092 BCX8">wo</span><span class="NormalTextRun SCXW167272092 BCX8">men=</span><span class="NormalTextRun SCXW167272092 BCX8">55.7%</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>vs</span><span> </span><span class="NormalTextRun SCXW167272092 BCX8">men=</span><span class="NormalTextRun SCXW167272092 BCX8">65.9%</span><span class="NormalTextRun SCXW167272092 BCX8">; p<0.001)</span><span class="NormalTextRun SCXW167272092 BCX8">.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1070659019" paraeid="{816baf6f-6194-4ada-85fa-bd940a6f6861}{237}"><span class="NormalTextRun SCXW167272092 BCX8">Women had higher postprocedural gradients compared with men (</span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">mean<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">transmitral</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>valve pressure gradient ≥</span><span class="NormalTextRun SCXW167272092 BCX8">5 mm</span><span class="NormalTextRun SCXW167272092 BCX8">Hg: 24.0% vs 14.0%; p< 0.001). Mild or less MR was similar between the two sexes (</span><span class="NormalTextRun SCXW167272092 BCX8">p=0.066).</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>Women were also less likely to receive guideline-directed medical therapy (GDMT).</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1822000378" paraeid="{b1b6326b-a662-4529-b282-ec96bfe26b81}{151}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">At 1-year follow-up,<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">11.0% of women and 12.1% of men died (hazard ratio [HR]=1.17, 95% confidence interval [CI]=0.83-1.65; p=0.361)</span><span class="NormalTextRun SCXW167272092 BCX8">.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1167754358" paraeid="{b8febc0d-48f3-4e6a-9f29-7447e82000db}{220}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Patients who had residual mild or less MR had lower rates of 1-year mortality (adjusted HR=0.57, 95% CI=0.38-0.84; p=0.005), but no</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>statistically significant</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>association was<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">observed</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>between gradients <</span><span class="NormalTextRun SCXW167272092 BCX8">5 mm</span><span class="NormalTextRun SCXW167272092 BCX8">Hg and 1-year mortality (p=0.056).</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1923627642" paraeid="{eca1afa4-282a-4df2-bfb1-985d11a5555d}{170}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Important limitations were listed for this study, including the fact that all data and imaging were collected at individual sites without independent adjudication, mean<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">trans</span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">mitral</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>pressure gradients were not heart rate adjusted, only some patients had follow-up echocardiographic data and long-term outcomes beyond 1-year were not evaluated.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1297733110" paraeid="{8af9847c-f689-40ae-8273-960ff6ee1e0c}{20}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">The investigators concluded that M-TEER with the PASCAL system is safe at 1-year, reduces MR and</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>is</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>technically successful in both men and women, though women have fewer<span> </span></span><span class="NormalTextRun SCXW167272092 BCX8">optimal</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>results post-procedure.</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1980498890" paraeid="{d48220b9-37f9-4069-b5a5-10426f22e989}{127}"><strong><span class="NormalTextRun SCXW167272092 BCX8">Source:</span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1591744734" paraeid="{d48220b9-37f9-4069-b5a5-10426f22e989}{223}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Von Stein P,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW167272092 BCX8">Schindhelm</span><span class="NormalTextRun SCXW167272092 BCX8"><span> </span>F, Rudolph F, et al. Sex-specific outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair: The REPAIR study.<em> </em></span></span><em><span class="NormalTextRun SCXW167272092 BCX8">JACC Adv</span></em><span class="NormalTextRun SCXW167272092 BCX8">. 2026 May 13 (Article in Press).</span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW167272092 BCX8"> <p class="Paragraph SCXW167272092 BCX8" lang="EN-US" paraid="1866051581" paraeid="{571da5c6-0095-40b2-ba35-b360caa2d352}{156}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW167272092 BCX8"><span class="NormalTextRun SCXW167272092 BCX8">Image Credit: </span><span class="NormalTextRun SCXW167272092 BCX8">MQ-Illustrations</span><span class="NormalTextRun SCXW167272092 BCX8"> – stock.adobe.com</span></span><span class="EOP SCXW167272092 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>