<div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="484552229" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{10}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Fewer w</span><span class="NormalTextRun SCXW141135177 BCX0">omen<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">are<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">undergoing transcatheter aortic valve implantation (TAVI)<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">and they<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">have more complications</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>after TAVI</span><span class="NormalTextRun SCXW141135177 BCX0">, but</span><span> </span><span class="NormalTextRun SCXW141135177 BCX0">higher chances of<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">long-term survival</span><span class="NormalTextRun SCXW141135177 BCX0">,</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>compared with men,</span><span> </span><span class="NormalTextRun SCXW141135177 BCX0">a new study comparing sex outcomes in TAVI</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>shows.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="1377709419" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{12}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">The corresponding data were reported by Johny Nicolas, MD, MSc, of the Icahn School of Medicine at Mount Sinai, New York, and colleagues, on</span><span class="NormalTextRun SCXW141135177 BCX0">line</span><span> </span><span class="NormalTextRun SCXW141135177 BCX0">Wednesday in<span> </span></span></span><em><span class="NormalTextRun SCXW141135177 BCX0">JAMA Cardiology</span></em><span class="NormalTextRun SCXW141135177 BCX0">.</span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="430161160" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{14}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Data on trends in TAVI usage,<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">outcomes</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and complications in men versus women are lacking. Investigators in this present study examined the 10-year data on TAVI use, complications and long-term effects in patients who are Medicare beneficiaries. T</span><span class="NormalTextRun SCXW141135177 BCX0">he differences between sexes were compared and analyzed.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="782944150" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{16}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">U.S. Medicare claims data<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">from the Centers for Medicare and Medicaid Services (CMS)<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">were analyzed in this nationwide, retrospective, population-based cohort study. Patients who underwent TAVI and were discharged from their respecti</span><span class="NormalTextRun SCXW141135177 BCX0">ve medical centers between January 1, 2013, and December 31, 2022, were included, and 2.19 years was the median follow-up time.</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>Data were analyzed between October 1, 2024, and April 1, 2025.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="2003674816" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{18}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Patients were excluded from the study if they had valve surgery, infective endocarditis, valve-in-valve TAVI, transapical TAVI or TAVI for pure aortic insufficiency, or if they switched to<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">the<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">Medica</span><span class="NormalTextRun SCXW141135177 BCX0">re Advantage health plan.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="462111413" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{20}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">All-cause death<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">6 years post-TAVI<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">was the primary outcome in this study. </span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="119464929" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{22}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Key secondary outcomes included periprocedural death, cardiac complications, acute kidney injury, significant bleeding, stroke, heart attack, permanent pacemaker implantation<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">(PPI</span><span class="NormalTextRun SCXW141135177 BCX0">)</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and hospitalization for heart failure (HF).</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="286542045" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{24}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">A total of<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">314,123 patients</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>were included</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>in this study (45% women, mean age=80.3 years</span><span class="NormalTextRun SCXW141135177 BCX0">, 91.9% White, 4.3% Black, 1.1% Hispanic</span><span class="NormalTextRun SCXW141135177 BCX0">; 55% men, mean age=79.4<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">years</span><span class="NormalTextRun SCXW141135177 BCX0">, 93.1% White, 2.7% Black, 0.8% Hispanic</span><span class="NormalTextRun SCXW141135177 BCX0">).</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>Common comorbidities in both groups included hypertension, hyperlipidemia,<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW141135177 BCX0">diabetes</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and a history of HF.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="125418858" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{26}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Fewer<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">women underwent TAVI in 2022 (43.6%) compared with 2013 (47.6%) (p<0.001).</span><span class="NormalTextRun SCXW141135177 BCX0"> </span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="523753556" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{28}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">More women had higher periprocedural mortality compared with men (2.5% versus 2.2%</span><span class="NormalTextRun SCXW141135177 BCX0">; adjusted odds ratio [AOR]=1.20, 95% confidence interval [CI]=1.14-1.26), as well as more vascular complications (5.8% versus 3.6%)</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>bl</span><span class="NormalTextRun SCXW141135177 BCX0">eeding events (10.4% versus 6.8%).</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="2031832221" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{30}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Women were at greater risk versus men for hospitalization due to HF, acute myocardial infarction (AMI),<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">stroke</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and bleeding.</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" paraid="1886276210" paraeid="{885519fd-b6d1-40d7-9ede-a7e90efcfa13}{32}"><span class="NormalTextRun SCXW141135177 BCX0">However, women had less PPI compared with men (16.9% versus 20.0%). Women also had lower long-term mortality risk versus men (adjusted hazard ratio [AHR]=0.92, 95% CI=0.91-0.93).</span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" lang="EN-US" paraid="1580739475" paraeid="{d3942529-c755-42ea-9e6e-06f1cfa4f6bf}{181}"><span class="NormalTextRun SCXW141135177 BCX0">This study revealed the risk differences in outcomes and TAVI experience in women compared with men, namely that women have higher complication rates and better long-term survival.</span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" lang="EN-US" paraid="1913625211" paraeid="{2092d6fa-b6d0-4c07-9611-29723ab5bc66}{44}"><strong><span class="NormalTextRun SCXW141135177 BCX0">Source:</span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" lang="EN-US" paraid="1839865323" paraeid="{2092d6fa-b6d0-4c07-9611-29723ab5bc66}{104}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Nicolas J,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW141135177 BCX0">Gelijns</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>AC, Moskowitz AJ, et al. Sex-based<span> </span></span><span class="NormalTextRun SCXW141135177 BCX0">patterns</span><span class="NormalTextRun SCXW141135177 BCX0"><span> </span>and trends in transcatheter aortic valve implantation.<span> </span></span></span><em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">JAMA </span><span class="NormalTextRun SpellingErrorV2Themed SCXW141135177 BCX0">Cardiol</span></span></em><span class="NormalTextRun SCXW141135177 BCX0">. 2026 May 6 (Article in Press).</span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW141135177 BCX0"> <p class="Paragraph SCXW141135177 BCX0" lang="EN-US" paraid="982940805" paraeid="{86550a26-5406-474c-999c-25cde4c7b26d}{87}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun MacChromeBold SCXW141135177 BCX0"><span class="NormalTextRun SCXW141135177 BCX0">Image Credit: </span><span class="NormalTextRun SpellingErrorV2Themed SCXW141135177 BCX0">alexmia</span><span class="NormalTextRun SCXW141135177 BCX0"> – stock.adobe.com</span></span><span class="EOP SCXW141135177 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>