<div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1270242122" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{10}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">Same day discharge</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>(SDD)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>following m</span><span class="NormalTextRun SCXW176855970 BCX0">itral transcatheter edge-to-edge repair (M-TEER)</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">carries</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>a similar 90-day readmission risk as an overnight stay, but with lower index hospitalization costs,<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">a new wide-scale registry study<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">reveals</span><span class="NormalTextRun SCXW176855970 BCX0">.<span> </span></span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1490662423" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{12}"><span class="NormalTextRun SCXW176855970 BCX0">The study was published online ahead of print in<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">JACC: Advances</span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">, led by</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>Mayo Clinic’s<span> </span></span></span><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">Mahmoud<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">Ismayl</span><span class="NormalTextRun SCXW176855970 BCX0">, MBBS</span><span class="NormalTextRun SCXW176855970 BCX0">. </span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="897270644" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{14}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">While M-TEER is a well-establishe</span><span class="NormalTextRun SCXW176855970 BCX0">d</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>and minimally invasive treatment of<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">severe symptomatic primary (degenerative) mitral regurgitation (MR)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>in patients at high or prohibitive surgical risk, as well as in certain secondary MR patients<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">who<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">remain</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>symptomatic despite guideline-directed medical therapy,<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">SDD<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">remains</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>uncommon.</span><span class="NormalTextRun SCXW176855970 BCX0"> </span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="988491983" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{16}"><span class="NormalTextRun SCXW176855970 BCX0">The practice has garnered<span> </span></span><a class="Hyperlink SCXW176855970 BCX0" href="https://pubmed.ncbi.nlm.nih.gov/37438024/" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW176855970 BCX0" data-ccp-charstyle="Hyperlink">increasing interest</span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>in recent years, however, the authors noted, with several<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">demonstrating</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>that it is<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">feasible</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>and safe</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>in certain<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">transcatheter aortic valve replacement (</span></span><a class="Hyperlink SCXW176855970 BCX0" href="https://pubmed.ncbi.nlm.nih.gov/35644697/" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW176855970 BCX0" data-ccp-charstyle="Hyperlink">TAVR</span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>or</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>left atrial appendage occlusion (</span></span><a class="Hyperlink SCXW176855970 BCX0" href="https://pubmed.ncbi.nlm.nih.gov/36638903/" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW176855970 BCX0" data-ccp-charstyle="Hyperlink">LAAO</span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>patients.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="139250914" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{18}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">The current study therefore set out to compile the first comprehensive feasibility and safety study of<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">SDD</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">among 39,804 weighted hospitalizations for M-TEER in the</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>U</span><span class="NormalTextRun SCXW176855970 BCX0">.</span><span class="NormalTextRun SCXW176855970 BCX0">S</span><span class="NormalTextRun SCXW176855970 BCX0">.</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">Nationwide Readmissions Database</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>between 2016 and 2022.<span> </span></span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1426730287" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{20}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">A total<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">498 (</span><span class="NormalTextRun SCXW176855970 BCX0">1.2%</span><span class="NormalTextRun SCXW176855970 BCX0">)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>of these<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">hospitalizations involved<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">SDD</span><span class="NormalTextRun SCXW176855970 BCX0">,<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">27,458 (69%) were discharged the next day<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">(NDD)<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">and 11,84</span><span class="NormalTextRun SCXW176855970 BCX0">8 (29.8%)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>were</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">discharged on the second or third day post-procedurally</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>(ScD/ TDD)</span><span class="NormalTextRun SCXW176855970 BCX0">. </span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="536237735" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{22}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">At baseline,<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">the ages of<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">the three groups<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">—</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">SDD</span><span class="NormalTextRun SCXW176855970 BCX0">,<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">NDD</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>and</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>ScD/TDD</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">—</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>were similar overall, though a<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">higher proportion of ScD/ TDD patients were younger (age 18 to 64 years; 17.5% vs<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">10.8% in same day and 10.1% in<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">NDD</span><span class="NormalTextRun SCXW176855970 BCX0">).</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">Sex weighting was also roughly<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW176855970 BCX0">similar</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>and</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>most patients were covered by Medicare (84.3% in<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">SDD vs 87% in NDD vs 81% in ScD/ TDD)</span><span class="NormalTextRun SCXW176855970 BCX0">.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1252593786" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{24}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">The researchers found that the proportion of SDD and NDD increased over time</span><span class="NormalTextRun SCXW176855970 BCX0">, from 0.4% and 47.9%, respectively in 2016 to 2.4% and 76.7% in 2022. ScD/TDD, on the other hand, decreased from 51.78% to 20.9% over the same period (all P trend < 0.001). </span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1744066702" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{26}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">SDD was associated with a similar risk of 90-day all-cause readmission (14.8% vs 12.5%; adjusted<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">hazard ratio [</span><span class="NormalTextRun SCXW176855970 BCX0">HR</span><span class="NormalTextRun SCXW176855970 BCX0">]</span><span class="NormalTextRun SCXW176855970 BCX0">: 1.25; 95%<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">confidence interval [</span><span class="NormalTextRun SCXW176855970 BCX0">CI</span><span class="NormalTextRun SCXW176855970 BCX0">]</span><span class="NormalTextRun SCXW176855970 BCX0">: 0.90-1.74)</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">—</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">the primary endpoint</span><span class="NormalTextRun SCXW176855970 BCX0">.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1770463997" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{28}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">It was also associated with similar secondary outcomes, including</span><span> </span><span class="NormalTextRun SCXW176855970 BCX0">heart failure</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>(HF)</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>readmission (4.4% vs 3.7%; adjusted HR: 1.22; 95% CI: 0.67-2.22)</span><span class="NormalTextRun SCXW176855970 BCX0">.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="147130995" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{30}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">Yet, SDD carried</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>significantly lower index hospitalization costs<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">at a median<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">of<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">$38,029 vs $43,319</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>for NDD (</span><span class="NormalTextRun SCXW176855970 BCX0">P = 0.03).<span> </span></span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="555126677" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{32}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">L</span><span class="NormalTextRun SCXW176855970 BCX0">onger hospital stays</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>for ScD/TDD patients were, in fact, associated with a higher 90-day HF readmission risk</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>alongside higher hospitalization costs (</span><span class="NormalTextRun SCXW176855970 BCX0">$49,648</span><span class="NormalTextRun SCXW176855970 BCX0">;<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">P < 0.001) compared to NDD</span><span class="NormalTextRun SCXW176855970 BCX0">, though not with higher</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>cost of</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>all-cause<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">90-day<span> </span></span><span class="NormalTextRun SCXW176855970 BCX0">readmissions</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>(</span><span class="NormalTextRun SCXW176855970 BCX0">$9,297 in ScD/</span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">TDDvs</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>14,348 in SDD vs $12,411 in NDD; P <0.001)</span><span class="NormalTextRun SCXW176855970 BCX0">. </span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="1489644821" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{34}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">“</span><span class="NormalTextRun SCXW176855970 BCX0">These findings support the feasibility of SDD following M-TEER in carefully selected patients, highlighting the need for prospective studies to further evaluate its safety and to refine criteria for optimal patient selection</span><span class="NormalTextRun SCXW176855970 BCX0">,” the researchers concluded.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="660818337" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{36}"><strong><span class="NormalTextRun SCXW176855970 BCX0">Sources:</span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" paraid="655122454" paraeid="{a84cfa55-7787-43e8-9c45-f88a61a53a40}{38}"><span data-contrast="auto" xml:lang="DE-CH" lang="DE-CH" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">Ismayl</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>M,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">Goldsweig</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>AM,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">Al</span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">khouli</span><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>M, et al.<span> </span></span></span><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">Feasibility and Safety of Same-Day Discharge Following Elective Mitral Transcatheter Edge-to-Edge Repair</span><span class="NormalTextRun SCXW176855970 BCX0">. </span></span><em><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">JACC: </span><span class="NormalTextRun SCXW176855970 BCX0">Adv</span></span></em><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0"><span> </span>2026; DOI: 10.1016/j.jacadv.2026.102</span><span class="NormalTextRun SCXW176855970 BCX0">656.</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW176855970 BCX0"> <p class="Paragraph SCXW176855970 BCX0" lang="EN-US" paraid="707858214" paraeid="{aead0f3f-22a4-4826-9c01-3af3928fdae1}{40}"><strong><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun MacChromeBold SCXW176855970 BCX0"><span class="NormalTextRun SCXW176855970 BCX0">Image Credit: </span><span class="NormalTextRun SpellingErrorV2Themed SCXW176855970 BCX0">Avocado_studio</span><span class="NormalTextRun SCXW176855970 BCX0"> – stock.adobe.com</span></span><span class="EOP SCXW176855970 BCX0" data-ccp-props="{}"> </span></strong></p> </div>