<div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1675100443" paraeid="{6b1081af-057a-4518-a7d5-5742cc483f8c}{13}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">Routine intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) does not lower the risk of target vessel failure (TVF) compared with angiography-guided PCI,<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">results from a randomized clinical trial show.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="202220954" paraeid="{81203137-3ce7-42b6-9768-7239befa1295}{119}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">Roberto<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW72417892 BCX0">Diletti</span><span class="NormalTextRun SCXW72417892 BCX0">, MD, PhD, of the<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW72417892 BCX0">Thoraxcenter</span><span class="NormalTextRun SCXW72417892 BCX0">, Erasmus Medical Center, Rotterdam, the Netherlands, presented these results on Monday during the final late-breaking clinical trials session at the American College of Cardiology (ACC) 2026 Scientific Sessions in New Orleans.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="811671919" paraeid="{8cb148db-8069-436e-a260-4c0c8ff3c7c5}{14}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">Data<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW72417892 BCX0">were simultaneously</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>published in the<span> </span></span></span><span class="NormalTextRun SCXW72417892 BCX0">New England Journal of Medicine.</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="314395430" paraeid="{280088d2-5418-4e2f-88f2-0c081f028788}{85}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">Prior research has<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">demonstrated</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>the benefits of IVUS-guided PCI for improving stent optimization and adverse event rates. Guidelines currently recommend IVUS-guided PCI for complex lesions, but data<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW72417892 BCX0">are</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>lacking.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1190320490" paraeid="{ff54d04d-c2d3-424e-8dec-5218a13c93df}{183}"><span class="NormalTextRun SCXW72417892 BCX0">Patients in this investigator-initiated, international, open-label, randomized controlled<span> </span></span><a class="Hyperlink SCXW72417892 BCX0" href="https://clinicaltrials.gov/study/NCT04854070" target="_blank" rel="noreferrer noopener"><span class="NormalTextRun SCXW72417892 BCX0" data-ccp-charstyle="Hyperlink">IVUS-CHIP</span></a><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>(Intravascular Ultrasound Guidance for Complex High-risk Indicated Procedures)<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">trial assigned patients to receive IVUS-guided PCI or angiography-guided PCI. Prespecified stent-optimization criteria were present in the IVUS group.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1755921932" paraeid="{cd71e125-5498-4f8f-85a2-5bc12230c2d7}{215}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">TVF, a composite of cardiovascular death, TV myocardial infarction or clinically<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">indicated</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>TV revascularization, was the primary endpoint in this study.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="900125918" paraeid="{17439ca7-8253-49ea-8256-d1fa0450a01b}{147}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">A total of 1,010 patients were in the IVUS group (mean age=69.5 years, 79.6% men) and 1,009 patients were in the angiography group (mean age=69.1 years, 79.3% men)<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">in the final analysis</span><span class="NormalTextRun SCXW72417892 BCX0">.</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>Of all the patients in the study, 27.4% had acute coronary syndrome.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1400391697" paraeid="{f7d00e98-eeac-4778-881b-d24a93365df3}{244}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">In the IVUS group, the mean procedural time was 88.8 minutes, and this time was 66.2 minutes in the angiography group.<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">During the IVUS-guided procedures, 91.3% of patients had dilation with balloon angioplasty after stent implantation was performed. This rate was lower in the angiography group at 84.5%.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1207086249" paraeid="{04b166f4-fded-4a49-8099-72703f628b9d}{167}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">The median follow-up time was 19.0 months.<span> </span></span><span class="NormalTextRun SCXW72417892 BCX0">At this time, 13.9% of patients in the IVUS group and 11.1% of patients in the angiography group experienced the TVF (p=0.08).</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="738084637" paraeid="{4a9aaef3-2c6c-4005-9d49-6a15d1945919}{114}"><span class="NormalTextRun SCXW72417892 BCX0">Procedural complications were similar between groups, as well as adverse event rates.</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="797482871" paraeid="{2a856e8e-3f61-4196-bf1e-bc4d9db9e02c}{45}"><span class="NormalTextRun SCXW72417892 BCX0">“</span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">Among patients undergoing complex high-risk PCI in current European practice, routine IVUS guidance did not reduce the rate of target-vessel failure compared with angiography guidance,” Dr.<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW72417892 BCX0">Diletti</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>concluded during his presentation.</span></span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1967056266" paraeid="{1cd4ef47-d1e0-477d-a3c2-4a1334468d5d}{2}"><strong><span class="NormalTextRun SCXW72417892 BCX0">This study was funded by Boston Scientific.</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="1749606328" paraeid="{1cd4ef47-d1e0-477d-a3c2-4a1334468d5d}{182}"><strong><span class="NormalTextRun SCXW72417892 BCX0">Source:</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="511206897" paraeid="{4caafeef-6ae8-41dc-81ca-e4d9bc87bf2a}{235}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SpellingErrorV2Themed SCXW72417892 BCX0">Diletti</span><span class="NormalTextRun SCXW72417892 BCX0"><span> </span>R, Daemen J, Faurie B, et al. Intravascular ultrasound-guided or angiography-guided complex high-risk PCI.<span> </span></span></span><em><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW72417892 BCX0"><span class="NormalTextRun SCXW72417892 BCX0">N</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW72417892 BCX0"> Engl</span><span class="NormalTextRun SCXW72417892 BCX0"> J Med</span></span></em><span class="NormalTextRun SCXW72417892 BCX0">. 2026 March 30 (Article in Press).</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW72417892 BCX0"> <p class="Paragraph SCXW72417892 BCX0" xml:lang="EN-US" lang="EN-US" paraid="768983629" paraeid="{1cd4ef47-d1e0-477d-a3c2-4a1334468d5d}{216}"><strong><span class="NormalTextRun SCXW72417892 BCX0">Image Credit: Screenshot by Bailey G. Salimes, CRTonline.org.</span><span class="EOP Selected SCXW72417892 BCX0" data-ccp-props="{}"> </span></strong></p> </div>