<div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="130422700" paraeid="{d049a4f1-f139-4c1f-a037-3e9a39169a71}{27}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">A state-of-the-art</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>review spotlights plaque erosion</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>in<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">patients with<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">acute coronary syndrome (ACS):<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">how<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">is<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">erosion<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">different from plaque rupture</span><span class="NormalTextRun SCXW235199119 BCX8">,<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">how does imaging help</span><span> </span><span class="NormalTextRun SCXW235199119 BCX8">with diagnosis<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">and<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">what’s</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>lacking?</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="652716520" paraeid="{8ec6b067-6f05-4d52-b9da-653061559610}{96}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Denitsa<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW235199119 BCX8">Meteva</span><span class="NormalTextRun SCXW235199119 BCX8">, MD, of the Charité University Medicine Berlin and Berlin Institute of Health (BIH), Germany</span><span class="NormalTextRun SCXW235199119 BCX8">, and colleagues from Italy, the Netherlands and the U.S., reported these findings in<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">a manuscript</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>published online in the<span> </span></span></span><span class="NormalTextRun SCXW235199119 BCX8">European Heart Journal</span><span class="NormalTextRun SCXW235199119 BCX8">.</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="526722362" paraeid="{cd4f66e1-f9a6-449e-8fa1-44692fb07d14}{50}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">ACS often begins with coronary atherosclerotic disease, which leads to plaque rupture and<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">thrombotic occlusion of the coronary arteries as a result. Recent studies<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">using optical coherence tomography (OCT)<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">have<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">demonstrated</span><span> </span><span class="NormalTextRun SCXW235199119 BCX8">that<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">there are more ACS cases with plaque erosion than<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">previously<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">thought.</span><span> </span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="809929860" paraeid="{0a0687fb-cbd9-4e80-8bba-da4fc9ab8c5c}{140}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">In cases of myocardial infarction (MI), OCT detected plaque erosion in 25%-44% of cases, but postmortem OCT only detected plaque erosion in 20%-25% of cases.<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">Despite this, 60%-70% of patients with ACS develop the condition due to plaque rupture. </span><span class="NormalTextRun SCXW235199119 BCX8">Plaque erosion is</span><span class="NormalTextRun SCXW235199119 BCX8"> also influenced by sex,<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">age</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>and common cardiovascular risk factors, like smoking.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="265641428" paraeid="{da7cf473-663b-4da0-b621-64888a285fbc}{122}"><span class="NormalTextRun SCXW235199119 BCX8">“It is crucial to distinguish between ACS resulting from obstructive epicardial coronary artery disease, such as the above mentioned and the broader category of myocardial infarctions occurring in the absence of obstructive coronary artery disease, known as MINOCA,” the researchers noted.</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="314817797" paraeid="{b83e1abf-a5e7-4aba-a0a7-529dbf12fe52}{17}"><span class="NormalTextRun SCXW235199119 BCX8">“Despite a favorable clinical phenotype, patients with MINOCA have a worse prognosis than individuals without cardiovascular disease, which is comparable to those with AMI and obstructive coronary artery disease (CAD).”</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="646319514" paraeid="{f10861ad-43cc-4c61-8be8-1f36a49c0d74}{245}"><strong><span class="NormalTextRun SCXW235199119 BCX8">Plaque erosion vs rupture</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="2036911192" paraeid="{b83e1abf-a5e7-4aba-a0a7-529dbf12fe52}{122}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Identifying</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>ruptured plaques is often easier than<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">identifying</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>eroded plaques on OCT</span><span class="NormalTextRun SCXW235199119 BCX8">, so other identifiers may be used to improve risk stratification. The researchers highlighted key differences between patients with plaque erosion versus rupture.<span> </span></span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="844553013" paraeid="{b2152884-93c3-41d3-bfd4-2ca96fd14497}{188}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Plaque erosion is more common in<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">younger<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">women<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">who are<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">under 6</span><span class="NormalTextRun SCXW235199119 BCX8">5</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>years of age, has fewer risk factors but is associated with smoking, creates local inflammation</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>rather than systemic inflammation</span><span class="NormalTextRun SCXW235199119 BCX8">, low-density lipoprotein (LDL)-cholesterol levels are lower</span><span class="NormalTextRun SCXW235199119 BCX8"> </span><span class="NormalTextRun SCXW235199119 BCX8">and often has better outcomes</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>compared with plaque rupture</span><span class="NormalTextRun SCXW235199119 BCX8">.<span> </span></span></span><span class="EOP SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1763726322" paraeid="{5b0f5332-e6cc-4152-b1ea-44fc2b5d41af}{111}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">As seen in OCT, no rupture fibrous cap will be present in patients with plaque erosion. Thrombus is present if<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">and if the<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">plaque is intact and<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">visible, t</span><span class="NormalTextRun SCXW235199119 BCX8">his<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">indicates</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>definite<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW235199119 BCX8">plaque</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>erosion. The patient<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">probably has</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>plaque erosion i</span><span class="NormalTextRun SCXW235199119 BCX8">f<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">there is no intac</span><span class="NormalTextRun SCXW235199119 BCX8">t plaque visible, but there<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">is</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>an irregular surface a</span><span class="NormalTextRun SCXW235199119 BCX8">long with no superficial lipid or calcium deposits around<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">the</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>lesion.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1487883740" paraeid="{3e887987-8a13-497c-9378-b204b27c2de9}{237}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">In<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">contrast</span><span class="NormalTextRun SCXW235199119 BCX8">, patients with plaque rupture are more likely to be men or older women</span><span class="NormalTextRun SCXW235199119 BCX8">;</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>ha</span><span class="NormalTextRun SCXW235199119 BCX8">ve diabetes, hyperlipoproteinemia or obesity;</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>have systemic inflammation; and have worse outcomes than patients with plaque erosion.</span><span> </span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="775526279" paraeid="{2f35fa9a-6f3f-4590-9c72-a85c7e2a57e1}{25}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">On OCT, patients with plaque rupture have a ruptured fibrous cap. If the plaque is lipid-rich with low signal region, high signal<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">attenuation</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>and poorly defined borders, this is indicative of plaque rupture. If the plaque is calcium-rich and protrudes into the lumen, and has thrombotic attachments, this is<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">likely a</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>calcified nodule.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1162689568" paraeid="{b1df4c28-ea6a-4a79-aefb-4348ff239857}{141}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">U</span><span class="NormalTextRun SCXW235199119 BCX8">nderstanding</span><span class="NormalTextRun SCXW235199119 BCX8"> plaque erosion</span><span class="NormalTextRun SCXW235199119 BCX8">: Can AI help?</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="436016668" paraeid="{70798ce5-5d88-48ff-80d2-aef9032650f6}{219}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Risk stratification for plaque erosion is a challenge.</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>Several mechanisms were described for plaque erosion</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>in comparison with plaque rupture</span><span class="NormalTextRun SCXW235199119 BCX8">, including higher myeloperoxidase (MPO) concentrations, lower white blood cell<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW235199119 BCX8">counts</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>and<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">more.</span><span class="NormalTextRun SCXW235199119 BCX8"> </span><span class="NormalTextRun SCXW235199119 BCX8">The investigators in this review suggested a combination of clinical, laboratory, and non-invasive imaging for the best prediction of plaque erosion.<span> </span></span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1378810993" paraeid="{f5a4f724-55d1-4475-94a4-7e2cdd249f7e}{152}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Artificial intelligence (AI)</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>models may be beneficial, too.<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">The deep-learning (DL) model called Transformer was able to differentiate between plaque rupture and erosion, compared with the Convolutional Neural Network (CNN) model,<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">utilizing</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>several adjacent OCT frames</span><span class="NormalTextRun SCXW235199119 BCX8">, in a recent trial.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="586691652" paraeid="{7b32993a-c1f7-42a6-9c63-ec722833fb95}{213}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">A newer DL model, called the Momentum Distillation-enhanced Composite Transformer Attention (MD-CTA), used<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">computed tomography angiography (CTA) to diagnose plaque<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">erosion</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>and<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">validated</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>the findings with OCT. This model outperformed the CNN model in both sensitivity and specificity.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="215020421" paraeid="{3d2191cc-1e72-4f3d-9710-86f29f965c11}{201}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Despite continued research, limitations in DL models<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">remain</span><span class="NormalTextRun SCXW235199119 BCX8">, and future research should focus on improving image quality,<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">enhancing specificity and<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW235199119 BCX8">sensitivity</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>and<span> </span></span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW235199119 BCX8">ensure</span><span> </span><span class="NormalTextRun SCXW235199119 BCX8">equitable</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>access to these models across regions, the researchers noted.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1643845648" paraeid="{9c8d81cb-363e-418d-b177-bf83677f813d}{127}"><strong><span class="NormalTextRun SCXW235199119 BCX8">Future research, addressing evidence gaps</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1791878446" paraeid="{9c8d81cb-363e-418d-b177-bf83677f813d}{68}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">The investigators concluded their review by highlighting the key unaddressed research areas in managing plaque erosion and ruptur</span><span class="NormalTextRun SCXW235199119 BCX8">e:</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>improv</span><span class="NormalTextRun SCXW235199119 BCX8">ed</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>diagnosis through non-invasive imaging and understanding biomarkers, a place where AI can<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">assist</span><span class="NormalTextRun SCXW235199119 BCX8">; personalized immunomodulatory treatments;<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">and secondary prevention and promotion of beneficial plaque healing.</span></span><span class="EOP SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1672654516" paraeid="{4ea6ba08-a018-4aa4-8a1a-a95c9b3e1315}{174}"><span class="NormalTextRun SCXW235199119 BCX8">“Beyond diagnosis, identifying pathomechanism-specific treatments is crucial. Plaque erosion involves less systemic inflammation but distinct local innate and adaptive immune activity,” the investigators wrote.</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1618223818" paraeid="{59936368-1630-475c-9476-c63d47a769fd}{147}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">“As current therapies<span> </span></span><span class="NormalTextRun SCXW235199119 BCX8">mainly target</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>plaque rupture, elucidating erosion-specific pathways is essential for developing tailored management strategies in precision cardiology.”</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1466616064" paraeid="{59936368-1630-475c-9476-c63d47a769fd}{227}"><strong><span class="NormalTextRun SCXW235199119 BCX8">Source:</span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="731769972" paraeid="{31abba45-9545-4788-bb19-0182378df938}{126}"><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SpellingErrorV2Themed SCXW235199119 BCX8">Meteva</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>D,<span> </span></span><span class="NormalTextRun SpellingErrorV2Themed SCXW235199119 BCX8">Pedicino</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>D, Abdelwahed YS, et al. Acute coronary syndrome with plaque erosion: clinical characteristics, mechanisms, and unmet needs. </span></span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SpellingErrorV2Themed SCXW235199119 BCX8">Eur</span><span class="NormalTextRun SCXW235199119 BCX8"><span> </span>Heart J</span></span><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">. 2026;47(12):1403-1414. doi:10.1093/</span><span class="NormalTextRun SpellingErrorV2Themed SpellingErrorHighlight SCXW235199119 BCX8">eurheartj</span><span class="NormalTextRun SCXW235199119 BCX8">/ehaf1004.</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></p> </div> <div class="OutlineElement Ltr SCXW235199119 BCX8"> <p class="Paragraph SCXW235199119 BCX8" xml:lang="EN-US" lang="EN-US" paraid="1290916350" paraeid="{31abba45-9545-4788-bb19-0182378df938}{203}"><strong><span data-contrast="auto" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW235199119 BCX8"><span class="NormalTextRun SCXW235199119 BCX8">Image Credit: daniiD</span><span class="NormalTextRun SCXW235199119 BCX8"> – stock.adobe.com</span></span><span class="EOP Selected SCXW235199119 BCX8" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":0,"335559739":160,"335559740":279}"> </span></strong></p> </div>