Abstract
In interventional cardiology, our efforts have traditionally centered on treating lesions in the epicardial coronary arteries, which can be visualized on coronary angiography. However, a significant proportion of patients experience similar symptoms to those with epicardial coronary artery lesions, yet without any angiographically visible coronary artery disease. These cases fall under the spectrum of coronary microvascular dysfunction. In this review, we will explore the disease's pathophysiology and focus on new frontiers in terms of diagnostic approaches and therapeutic strategies according to different endotypes.