Recent developments of interest in cardiovascular medicine
Novel twice-a-year cholesterol drug inclisiran beat statins alone for LDL lowering, according to topline results from the phase III ORION-11 trial announced ahead of presentation at the European Society of Cardiology meeting. Forbes notes that CV outcomes and price will be key, and Endpoints News further lays out the possible market shakeup.
The European Society of Cardiology also made a late addition to the late-breaking trials in Paris: DAPA HF -- The Dapagliflozin And Prevention Of Adverse-outcomes In Heart Failure Trial.
Cardiology compensation continues to climb
, up 3% year over year, with electrophysiologists coming out on top and heart failure specialists coming out 10% under other general non-invasive cardiologists, MedAxiom's survey showed.
Is the keto diet healthy? More than 70 trials looking at its impact on brain, cardiovascular, and metabolic health are underway or in the works, according to ClinicalTrials.gov, as noted in the New York Times.
Acute heart failure decompensation is an important event but not a good target for interventions to impact long-term outcomes, which takes intensive outpatient care, argued Milton Packer in an editorial to go along with the belated publication of the RELAX-AHF 2 trial results (2 years after presentation).
"In the modern era characterized by widespread statin use and cancer screening, aspirin does not reduce the risk of non-fatal MI or cancer death," concluded a meta-analysis comparing new and old aspirin studies on the preprint site medRxiv.
Cardiac transplantation at Jewish Hospital in Louisville, Kentucky, got a stay of (voluntary) execution with help for the program from the University of Louisville. (Wave 3 News)
Left-ventricular hypertrophy predicted coronary artery disease-related death and heart failure better than did coronary artery calcium score, found a study in Radiology.
FDA fast-tracked istaroxime, an IV agent for acute heart failure with reduced ejection fraction that is designed to increase both myocardial contractility and relaxation. (Cardiovascular Business)
A novel agent given after stroke or heart attack boosted transformation of surrounding cells into new neurons in a rodent model. (FierceBiotech)
Lower blood pressure thresholds may be even better for higher cardiorenal risk patients in terms of overall survival, a Korean study suggested. (JAMA Network Open)
A British cardiologist lost his license when he implanted the wrong type of pacemakerand then destroyed the medical record notes he had failed to examine beforehand. (BMJ)
Read the original article on Medpage Today: Inclisiran Wins on LDL; Cardio Salaries Climb; Is Keto Healthy?