• Vitamin D deficiency and periprocedural myocardial infarction in patients undergoing percutaneous coronary interventions

    Abstract

    Vitamin D deficiency has been implicated in the progression of atherosclerosis and acute thrombotic events. We aimed at evaluating the impact of vitamin D deficiency on periprocedural myocardial infarction (PMI) in patients undergoing percutaneous coronary interventions (PCI).

    We included 934 patients undergoing non-urgent PCI. Assessment of myocardial biomarkers was performed from 6 to 48 h after PCI. PMI was defined as Creatine Kinase-MB increase by 3 times the Upper Limit Normal or by 50% of an elevated baseline value, periprocedural myocardial damage as Troponin I increase by 3 × ULN or 50% of baseline.

    Patients were divided according to vitamin D tertiles values (<10.2 ng/ml; 10.2–18.7 ng/ml; ≥18.8 ng/ml). Lower tertiles values of vitamin D were associated with age (p = 0.04), female gender, (p = 0.001), and a higher cardiovascular risk profile. Lower vitamin D levels related with PCI of descending anterior coronary artery or bypass vein grafts (p = 0.03), treatment of bifurcations (p = 0.05) and side branch loss (p = 0.05) and inversely with direct stenting (p = 0.002). However, lower vitamin D levels did not influence the risk of PMI (adjusted OR [95% CI] = 0.81[0.65,1.18], p = 0.09) or periprocedural myocardial damage (adjusted OR [95% CI] = 0.93[0.77,1.13], p = 0.48). Similar results were achieved when considering the severity of vitamin D deficiency.

    Therefore, in patients undergoing PCI, no association was observed between vitamin D deficiency and the risk of periprocedural MI and myocardial damage.

    Highlights

     

    • Pro-thrombotic conditions can affect procedural results after percutaneous coronary intervention (PCI).

    • Multiple effects on inflammatory system and prevention of atherothrombosis have been descrived for vitamin D.

    • We evaluated the impact of vitamin D levels on periprocedural myocardial infarction or myonecrosis.

    • Vitamin D deficiency was frequently observed in our cohort of 934 patients undergoing non-urgent PCI.
    • Our main finding is that vitamin D levels are not associated with increased risk of periprocedural MI and myonecrosis.

    Author bio

    Cardiovascular Revascularization Medicine, 2018-10-01, Volume 19, Issue 7, Pages 744-750, Copyright © 2018 Elsevier Inc.

     

    Source:

    Cardiovascular Revascularization Medicine, 2018-10-01, Volume 19, Issue 7, Pages 744-750, Copyright © 2018 Elsevier Inc.

     

    Click here to read the full article

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Review our Privacy Policy for more details